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Literature summary for 3.4.21.75 extracted from
- Characterization of a secreted form of human furin endoprotease (1993), Biochem. Biophys. Res. Commun., 195, 1011-1018.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| Golgi membrane | the membrane-bound enzyme undergoes post-translational processing to produce a soluble form of the enzyme that can be secreted | Homo sapiens | 139 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, 26% loss of activity of furin mutant hFUR713t, 21% loss of activity of soluble furin after 3 weeks, optimal conditions of conservation are at 50% glycerol | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Preference for Arg-Glu-Lys-Arg-+-Ala vs. Lys-Ala-Lys-Arg-+-Arg | Homo sapiens | ? | - |
? |  |
| additional information | peptides patterned on the sequence 307-330 of the specific viral strains of the gp120 V3 loop | Homo sapiens | ? | - |
? | |
| tert-butoxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | tert-butoxycarbonyl-Arg-Val-Arg-Arg + 7-amino-4-methylcoumarin | - |
? | |
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