Literature summary for 3.4.21.73 extracted from

Yang, Y.; Friggeri, A.; Banerjee, S.; Bdeir, K.; Cines, D.B.; Liu, G.; Abraham, E.
Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils (2010), Am. J. Respir. Crit. Care Med., 182, 1516-1523.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Mus musculus C57BL/6	-	-	-

Synonyms

Synonyms	Comment	Organism
uPA	-	Mus musculus
Urokinase-type plasminogen activator	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	urokinase-type plasminogen activator is involved in diverse physiologic and pathophysiologic processes, including fibrinolysis, cell migration and adhesion, and inflammation, thereby playing a role in efferocytosis. uPA inhibits the uptake of apoptotic neutrophils, suggest a novel mechanism by which elevated levels of uPA may participate in enhancing the duration and severity of inflammatory processes, such as acute lung injury. The phagocytosis of apoptotic neutrophils by macrophages is significantly inhibited by uPA, the process requires the kringle domain of uPA, and involves alphaVbeta3 integrin and vitronectin. But protease activity is not required for uPA to inhibit the engulfment of apoptotic neutrophils by macrophages, overview. Wild-type and inactive uPA are able to inhibit phagocytosis of apoptotic neutrophils by macrophages	Mus musculus

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Release 2023.1 (January 2023)