Cloned (Comment) | Organism |
---|---|
mutant C122S expressed in Escherichia coli inclusion bodies, B-chain uPA expressed in S. pastoris | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
beta-c-uPA in complex with inhibitor UPA-I1, space group P2(1)2(1)2(1), cell constants a = 53.2 A, b = 54.7 A, c = 82.4 A, beta-c-uPA in complex with inhibitor UPA-I3, space group P2(1)2(1)2(1), cell constants a = 52.9 A, b = 54.7 A, c = 81.4 A, beta-c-uPA in complex with inhibitor UPA-I2, space group P2(1)2(1)2(1), cell constants a = 53.0 A, b = 54.4 A, c = 82.2 A, beta-c-uPA in complex with inhibitor UPA-I5, space group P2(1)2(1)2(1), cell constants a = 53.0 A, b = 54.9 A, c = 82.3 A, beta-c-uPA in complex with inhibitor UPA-I6, space group P2(1)2(1)2(1), cell constants a = 53.5 A, b = 54.8 A, c = 82.4 A, complex by soaking, Ybeta-c-uPA in complex with inhibitor UPA-I6, space group P4(3)2(1)2, cell constants a = 76.7 A, b = 76.7 A, c = 127.5 A, complex by Co-crystallization, beta-c-uPA in complex with inhibitor UPA-I4, space group P4(1)2(1)2, cell constants a = 55.0 A, b = 55.0 A, c = 151.6 A, complex by Co-crystallization | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C122S | mutant of the serine proteinase domain | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phenethylsulfonamidino-D-seryl-L-alanyl(P2)-L-argininal | - |
Homo sapiens | |
phenethylsulfonamidino-D-seryl-L-alanyl-L-argininal | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55000 | - |
- |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-pyroglutamyl-glycyl-L-arginine-p-nitroanilide + H2O | - |
Homo sapiens | L-pyroglutamyl-glycyl-L-arginine + 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
urokinase type plasminogen activator | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000002 | - |
phenethylsulfonamidino-D-seryl-L-alanyl(P2)-L-argininal | pH 7.4, 37°C, compound uPA-I5 | Homo sapiens | |
0.000003 | - |
phenethylsulfonamidino-D-seryl-L-alanyl(P2)-L-argininal | pH 7.4, 37°C, compound uPA-I6 | Homo sapiens | |
0.000006 | - |
phenethylsulfonamidino-D-seryl-L-alanyl(P2)-L-argininal | pH 7.4, 37°C, compound uPA-I3 | Homo sapiens | |
0.000014 | - |
phenethylsulfonamidino-D-seryl-L-alanyl(P2)-L-argininal | pH 7.4, 37°C, compound uPA-I4 | Homo sapiens | |
0.000021 | - |
phenethylsulfonamidino-D-seryl-L-alanyl(P2)-L-argininal | pH 7.4, 37°C, compound uPA-I1 | Homo sapiens | |
0.000028 | - |
phenethylsulfonamidino-D-seryl-L-alanyl(P2)-L-argininal | pH 7.4, 37°C, compound uPA-I2 | Homo sapiens |