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Literature summary for 3.4.21.73 extracted from

  • Verner, E.; Katz, B.A.; Spencer, J.R.; Allen, D.; Hataye, J.; Hruzewicz, W.; Hui, H.C.; Kolesnikov, A.; Li, Y.; Luong, C.; Martelli, A.; Radika, K.; Rai, R.; She, M.; Shrader, W.; Sprengeler, P.A.; Trapp, S.; Wang, J.; Young, W.B.; Mackman, R.L.
    Development of serine protease inhibitors displaying a multicentered short 2.3 ANG hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa (2001), J. Med. Chem., 44, 2753-2771.
    View publication on PubMed
Search for more literature for 3.4.21.73

Inhibitors

Inhibitors Comment Organism Structure
2-(1-hydroxynaphthalen-2-yl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2,6-dihydroxyphenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-3-bromo-5-methylphenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-3-bromophenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-3-fluorophenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-3-methoxyphenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-3-methylphenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-3-nitrophenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-4-diethylaminophenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-4-methylphenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-5-bromophenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-5-chlorobiphenyl-3-yl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-5-fluorophenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-5-methoxyphenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-5-methylphenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxy-5-nitrophenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxybiphenyl-3-yl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxyphenyl)-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-(2-hydroxyphenyl)1H-benzoimidazole-5-carboxamidine
-
 Homo sapiens
2-phenyl-1-H-benzoimidazole-5-carboxamidine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Synonyms

Synonyms Comment Organism
Urokinase-type plasminogen activator
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00025
-
 2-(2-hydroxy-3-bromophenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.00028
-
 2-(2-hydroxy-3-bromo-5-methylphenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.0004
-
 2-(2-hydroxybiphenyl-3-yl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.0005
-
 2-(2-hydroxy-5-chlorobiphenyl-3-yl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.00055
-
 2-(2-hydroxy-3-fluorophenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.0009
-
 2-(2-hydroxy-3-nitrophenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.0019
-
 2-(2,6-dihydroxyphenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.0028
-
 2-(2-hydroxy-5-fluorophenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.0033
-
 2-(2-hydroxy-5-nitrophenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.0036
-
 2-(2-hydroxy-5-methoxyphenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.0036
-
 2-(2-hydroxy-3-methoxyphenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.0036
-
 2-(2-hydroxy-4-methylphenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.0037
-
 2-(2-hydroxy-5-bromophenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.0039
-
 2-(1-hydroxynaphthalen-2-yl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.0055
-
 2-(2-hydroxyphenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.0075
-
 2-(2-hydroxy-5-methylphenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.008
-
 2-(2-hydroxy-3-methylphenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.013
-
 2-(2-hydroxy-4-diethylaminophenyl)-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens
0.055
-
 2-phenyl-1-H-benzoimidazole-5-carboxamidine pH 7.4, 37°C Homo sapiens