Application | Comment | Organism |
---|---|---|
medicine | associated with tumor metastasis and invasion, selective inhibitors of uPA may have potential as therapeutically useful drugs for prostate, breast and other cancers | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cloning of low molecular weight uPA, expression in Pichia pastoris | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
crystallized by vapor diffusion in hanging drops in complex with 4-iodobenzo[b]thiophene-2-carboxamidine and benzamidine, space group C2, ProteinDataBank accession code 1C5Z for uPA-benzamidine, 1C5Y for uPA-thieno[2,3-b]pyridine-2-carboxamidine | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-iodobenzo[b]thiophene-2-carboxamidine | APC-6860, competitive inhibition | Homo sapiens | |
benzamidine | - |
Homo sapiens | |
benzo[b]thiophene-2-carboxamidine | APC-7377 | Homo sapiens | |
thieno[2,3-b]pyridine-2-carboxamidine | APC-7538 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Urokinase-type plasminogen activator | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00021 | - |
4-iodobenzo[b]thiophene-2-carboxamidine | pH 7.4, 37°C | Homo sapiens | |
0.0023 | - |
benzo[b]thiophene-2-carboxamidine | pH 7.4, 37°C | Homo sapiens | |
0.063 | - |
thieno[2,3-b]pyridine-2-carboxamidine | pH 7.4, 37°C | Homo sapiens | |
0.097 | - |
benzamidine | pH 7.4, 37°C | Homo sapiens |