Literature summary for 3.4.21.72 extracted from

Lechner, S.M.; Abbad, L.; Boedec, E.; Papista, C.; Le Stang, M.B.; Moal, C.; Maillard, J.; Jamin, A.; Bex-Coudrat, J.; Wang, Y.; Li, A.; Martini, P.G.; Monteiro, R.C.; Berthelot, L.
IgA1 protease treatment reverses mesangial deposits and hematuria in a model of IgA nephropathy (2016), J. Am. Soc. Nephrol., 27, 2622-2629 .

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Cloned(Commentary)

Cloned (Comment)	Organism
recombinant intracellular expression of the enzyme in inclusion bodies in Escherichia coli in fed-batch fermentation	Haemophilus influenzae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
immunglobulin A1 + H2O	Haemophilus influenzae	-	immunglobulin Fc + immunglobulin Fd	-	?

Organism

Organism	UniProt	Comment	Textmining
Haemophilus influenzae	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant refolded enzyme solubilized from Escherichia coli inclusion bodies by ion exchange and hydrophobic interaction chromatography, followed by ultrafiltration and diafiltration	Haemophilus influenzae

Renatured (Commentary)

Renatured (Comment)	Organism
recombinant enzyme from Escherichia coli inclusion bodies by urea solubilization and refolding	Haemophilus influenzae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
immunglobulin A1 + H2O	-	Haemophilus influenzae	immunglobulin Fc + immunglobulin Fd	-	?

Synonyms

Synonyms	Comment	Organism
IgA1 protease	-	Haemophilus influenzae
IgA1?P	-	Haemophilus influenzae

General Information

General Information	Comment	Organism
physiological function	IgA1 protease treatment reverses mesangial deposits and hematuria in a model of IgA nephropathy, overview	Haemophilus influenzae

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Release 2023.1 (January 2023)