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Literature summary for 3.4.21.72 extracted from

  • Gallo, M.C.; Kirkham, C.; Eng, S.; Bebawee, R.S.; Kong, Y.; Pettigrew, M.M.; Tettelin, H.; Murphy, T.F.
    Changes in IgA protease expression are conferred by changes in genomes during persistent infection by nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease (2018), Infect. Immun., 86, e00313-18 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene igA1, genotyping and expression analysis Haemophilus influenzae NTHI
gene igB2, genotyping and expression analysis, expression of IgA protease B2 varies throughout the duration of persistence. Expression of IgA protease B2 during persistence in COPD is dynamic, and the frequent changes in expression are regulated by slipped-strand mispairing of the igaB2 gene Haemophilus influenzae NTHI

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae NTHI
-
 nontypeable Haemophilus influenzae
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
IgA protease A1
-
 Haemophilus influenzae NTHI
IgA protease B2
-
 Haemophilus influenzae NTHI
IgaA1
-
 Haemophilus influenzae NTHI
IgaB2
-
 Haemophilus influenzae NTHI

General Information

General Information Comment Organism
evolution expression of IgA proteases is variable from strain to strain among NTHi. Analysis of IgA protease expression by 101 persistent strains (median duration of persistence) collected longitudinally from patients enrolled in a 20-year study of COPD upon initial acquisition and immediately before clearance from the host. Upon acquisition, 89 (88%) express IgA protease. A total of 16 of 101 (16%) strains of NTHi alter expression of IgA protease during persistence. Indels and slipped-strand mispairing of mononucleotide repeats confer changes in expression of igaA2. Mechanism of changes in expression, overview Haemophilus influenzae NTHI
physiological function nontypeable Haemophilus influenzae (NTHi) expresses four IgA protease variants (A1, A2, B1, and B2) that play different roles in virulence Haemophilus influenzae NTHI
physiological function nontypeable Haemophilus influenzae (NTHi) expresses four IgA protease variants (A1, A2, B1, and B2) that play different roles in virulence. Expression of IgA protease B2 during persistence in COPD is dynamic and the frequent changes in expression are regulated by slipped-strand mispairing of the igaB2 gene Haemophilus influenzae NTHI