Application | Comment | Organism |
---|---|---|
analysis | the ability of IgA1 protease to cleave exclusively IgA1 without affecting IgA2 molecules allows a more economical and reliable method for determination of these antibody subclasses in human sera based on recombinant Neisseria meningitidis IgA1 protease. Estimation of IgA1 and IgA2 content in human serum and of IgA subclass levels and IgA1/IgA2 ratio using recombinant active and inactive forms of IgA1 protease from Neisseria meningitidis, method evaluation, overview | Neisseria meningitidis serogroup B |
Protein Variants | Comment | Organism |
---|---|---|
S267A | site-directed mutagenesis, catalytically inactive mutant | Neisseria meningitidis serogroup B |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
107000 | - |
- |
Neisseria meningitidis serogroup B |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
immunglobulin A1 + H2O | Neisseria meningitidis serogroup B | IgA1 from human serum | immunglobulin Fc + immunglobulin Fd | - |
? | |
immunglobulin A1 + H2O | Neisseria meningitidis serogroup B H44/76 | IgA1 from human serum | immunglobulin Fc + immunglobulin Fd | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Neisseria meningitidis serogroup B | - |
- |
- |
Neisseria meningitidis serogroup B H44/76 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
immunglobulin A1 + H2O | IgA1 from human serum | Neisseria meningitidis serogroup B | immunglobulin Fc + immunglobulin Fd | - |
? | |
immunglobulin A1 + H2O | IgA1 from human serum | Neisseria meningitidis serogroup B H44/76 | immunglobulin Fc + immunglobulin Fd | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IgA1 protease | - |
Neisseria meningitidis serogroup B |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Neisseria meningitidis serogroup B |
General Information | Comment | Organism |
---|---|---|
malfunction | the IgA1/IgA2 ratio is 6.3 for the healthy volunteers and 12.8 for patients with meningitis. IgA2 for the patients with meningitis and the healthy volunteers are almost unchanged, 1:86 and 1:121, respectively | Neisseria meningitidis serogroup B |
physiological function | ability of IgA1 protease to cleave exclusively IgA1 without affecting IgA2 molecules | Neisseria meningitidis serogroup B |