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Literature summary for 3.4.21.72 extracted from

  • Roussel-Jazede, V.; Arenas, J.; Langereis, J.D.; Tommassen, J.; van Ulsen, P.
    Variable processing of the IgA protease autotransporter at the cell surface of Neisseria meningitidis (2014), Microbiology, 160, 2421-2431.
    View publication on PubMed
Search for more literature for 3.4.21.72

Cloned(Commentary)

Cloned (Comment) Organism
-
 Neisseria meningitidis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane IgA protease of Neisseria meningitidis consists of an N-terminal signal sequence, a passenger domain and a C-terminal translocator domain that assists in the secretion of the passenger domain across the outer membrane. The protease domain is released into the extracellular milieu either via autocatalytic processing or via cleavage by the autotransporter NalP Neisseria meningitidis 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
106000
-
 x * 106000, protease domain, SDS-PAGE Neisseria meningitidis
170000
-
 x * 170000, full-length protein, SDS-PAGE Neisseria meningitidis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
human immunoglobulin A1 + H2O Neisseria meningitidis
-
 immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
human immunoglobulin A1 + H2O Neisseria meningitidis H44/76
-
 immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?

Organism

Organism UniProt Comment Textmining
Neisseria meningitidis
-
-
-
Neisseria meningitidis H44/76
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human immunoglobulin A1 + H2O
-
 Neisseria meningitidis immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
human immunoglobulin A1 + H2O
-
 Neisseria meningitidis H44/76 immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?

Subunits

Subunits Comment Organism
? x * 106000, protease domain, SDS-PAGE Neisseria meningitidis
? x * 170000, full-length protein, SDS-PAGE Neisseria meningitidis

Synonyms

Synonyms Comment Organism
IgA protease
-
 Neisseria meningitidis