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Literature summary for 3.4.21.72 extracted from

  • Yagudaeva, E.; Zhigis, L.; Razgulyaeva, O.; Zueva, V.; Melnikov, E.; Zubov, V.; Kozlov, L.; Bichucher, A.; Kotelnikova, O.; Alliluev, A.; Avakov, A.; Rumsh, L.
    Isolation and determination of the activity of IgA1 protease from Neisseria meningitidis (2010), Russ. J. Bioorg. Chem., 36, 81-89.
    View publication on PubMed
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
120000
-
 x * 120000, SDS-PAGE Neisseria meningitidis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
human IgA1 + H2O Neisseria meningitidis the enzyme possesses a unique substrate specificity to immunoglobulin A1 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Neisseria meningitidis
-
 serogroup A
-

Purification (Commentary)

Purification (Comment) Organism
development and evaluation of a method for isolation and purification of IgA1 protease from a culture of Neisseria meningitidis serogroup A, purification involves absorption, hydrophobic interaction, anion exchange, and jacalin affinity chromatography steps, to homogeneity, overview Neisseria meningitidis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human IgA1 + H2O the enzyme possesses a unique substrate specificity to immunoglobulin A1 Neisseria meningitidis ?
-
 ?

Subunits

Subunits Comment Organism
? x * 120000, SDS-PAGE Neisseria meningitidis

Synonyms

Synonyms Comment Organism
IgA1 protease
-
 Neisseria meningitidis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
 assay at Neisseria meningitidis

General Information

General Information Comment Organism
additional information IgA1 protease isolated from serogroup A meningococcus is capable of protecting experimental mice infected with meningococcus of serogroup B Neisseria meningitidis