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Literature summary for 3.4.21.72 extracted from
- Immunoglobulin A1 protease: a new therapeutic candidate for immunoglobulin A nephropathy (2010), Nephrology, 15, 584-586.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | IgA1 protease may be an effective therapeutic candidate for IgAN by removing the mesangial deposited IgA1 in glomerular mesangium leading to immunoglobulin A nephropathy. The removal of IgA1 by IgA1 protease may separate the IgA1-containing immune complexes thereby eliminating its other components at the same time | Haemophilus influenzae |
| medicine | IgA1 protease may be an effective therapeutic candidate for IgAN by removing the mesangial deposited IgA1 in glomerular mesangium leading to immunoglobulin A nephropathy. The removal of IgA1 by IgA1 protease may separate the IgA1-containing immune complexes thereby eliminating its other components at the same time | Neisseria gonorrhoeae |
| medicine | IgA1 protease may be an effective therapeutic candidate for IgAN by removing the mesangial deposited IgA1 in glomerular mesangium leading to immunoglobulin A nephropathy. The removal of IgA1 by IgA1 protease may separate the IgA1-containing immune complexes thereby eliminating its other components at the same time | Neisseria meningitidis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| human IgA1 + H2O | Haemophilus influenzae | IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 | ? | - |
? |  |
| human IgA1 + H2O | Neisseria gonorrhoeae | IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 | ? | - |
? | |
| human IgA1 + H2O | Neisseria meningitidis | IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Haemophilus influenzae | - |
- |
- |
| Neisseria gonorrhoeae | - |
- |
- |
| Neisseria meningitidis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| human IgA1 + H2O | IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 | Haemophilus influenzae | ? | - |
? | |
| human IgA1 + H2O | IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 | Neisseria gonorrhoeae | ? | - |
? | |
| human IgA1 + H2O | IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 | Neisseria meningitidis | ? | - |
? | |
| human IgA1 + H2O | human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease | Haemophilus influenzae | ? | - |
? | |
| human IgA1 + H2O | human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease | Neisseria gonorrhoeae | ? | - |
? | |
| human IgA1 + H2O | human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease | Neisseria meningitidis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IgA1 protease | - |
Haemophilus influenzae |
| IgA1 protease | - |
Neisseria gonorrhoeae |
| IgA1 protease | - |
Neisseria meningitidis |
| immunoglobulin A1 protease | - |
Haemophilus influenzae |
| immunoglobulin A1 protease | - |
Neisseria gonorrhoeae |
| immunoglobulin A1 protease | - |
Neisseria meningitidis |
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Release 2023.1 (January 2023)
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