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Literature summary for 3.4.21.72 extracted from

  • Senior, B.W.; Woof, J.M.
    Effect of mutations in the human immunoglobulin A1 (IgA1) hinge on its susceptibility to cleavage by diverse bacterial IgA1 proteases (2005), Infect. Immun., 73, 1515-1522.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IgA1 + H2O Haemophilus influenzae
-
?
-
?
IgA1 + H2O Neisseria gonorrhoeae
-
?
-
?
IgA1 + H2O Neisseria meningitidis
-
?
-
?
IgA1 + H2O Streptococcus pneumoniae
-
?
-
?
IgA1 + H2O Streptococcus sanguinis
-
?
-
?
IgA1 + H2O Streptococcus mitis
-
?
-
?
IgA1 + H2O Streptococcus oralis
-
?
-
?
IgA1 + H2O Streptococcus mitis SK599
-
?
-
?
IgA1 + H2O Streptococcus mitis SK597
-
?
-
?
IgA1 + H2O Streptococcus oralis SK10
-
?
-
?
IgA1 + H2O Streptococcus sanguinis SK4
-
?
-
?
IgA1 + H2O Streptococcus pneumoniae SK690
-
?
-
?
IgA1 + H2O Streptococcus sanguinis SK1
-
?
-
?
IgA1 + H2O Streptococcus sanguinis SK49
-
?
-
?
IgA1 + H2O Streptococcus mitis SK564
-
?
-
?

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
-
H15 type 2
-
Haemophilus influenzae
-
H23 type 1
-
Neisseria gonorrhoeae
-
5489 type 2
-
Neisseria gonorrhoeae
-
6092 type 1
-
Neisseria meningitidis
-
HF13 type 2
-
Neisseria meningitidis Q9K0B4 3564 type 1
-
Streptococcus mitis
-
SK564
-
Streptococcus mitis
-
SK597
-
Streptococcus mitis
-
SK599
-
Streptococcus mitis SK564
-
SK564
-
Streptococcus mitis SK597
-
SK597
-
Streptococcus mitis SK599
-
SK599
-
Streptococcus oralis
-
SK10
-
Streptococcus oralis SK10
-
SK10
-
Streptococcus pneumoniae
-
SK690
-
Streptococcus pneumoniae SK690
-
SK690
-
Streptococcus sanguinis
-
SK1
-
Streptococcus sanguinis
-
SK4
-
Streptococcus sanguinis
-
SK49
-
Streptococcus sanguinis SK1
-
SK1
-
Streptococcus sanguinis SK4
-
SK4
-
Streptococcus sanguinis SK49
-
SK49
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IgA1 + H2O
-
Haemophilus influenzae ?
-
?
IgA1 + H2O
-
Neisseria gonorrhoeae ?
-
?
IgA1 + H2O
-
Neisseria meningitidis ?
-
?
IgA1 + H2O
-
Streptococcus pneumoniae ?
-
?
IgA1 + H2O
-
Streptococcus sanguinis ?
-
?
IgA1 + H2O
-
Streptococcus mitis ?
-
?
IgA1 + H2O
-
Streptococcus oralis ?
-
?
IgA1 + H2O pH 7.2, 37°C Haemophilus influenzae ?
-
?
IgA1 + H2O pH 7.2, 37°C Neisseria gonorrhoeae ?
-
?
IgA1 + H2O pH 7.2, 37°C Neisseria meningitidis ?
-
?
IgA1 + H2O pH 7.2, 37°C Streptococcus pneumoniae ?
-
?
IgA1 + H2O pH 7.2, 37°C Streptococcus sanguinis ?
-
?
IgA1 + H2O pH 7.2, 37°C Streptococcus mitis ?
-
?
IgA1 + H2O pH 7.2, 37°C Streptococcus oralis ?
-
?
IgA1 + H2O
-
Streptococcus mitis SK599 ?
-
?
IgA1 + H2O pH 7.2, 37°C Streptococcus mitis SK599 ?
-
?
IgA1 + H2O
-
Streptococcus mitis SK597 ?
-
?
IgA1 + H2O pH 7.2, 37°C Streptococcus mitis SK597 ?
-
?
IgA1 + H2O
-
Streptococcus oralis SK10 ?
-
?
IgA1 + H2O pH 7.2, 37°C Streptococcus oralis SK10 ?
-
?
IgA1 + H2O
-
Streptococcus sanguinis SK4 ?
-
?
IgA1 + H2O pH 7.2, 37°C Streptococcus sanguinis SK4 ?
-
?
IgA1 + H2O
-
Streptococcus pneumoniae SK690 ?
-
?
IgA1 + H2O pH 7.2, 37°C Streptococcus pneumoniae SK690 ?
-
?
IgA1 + H2O
-
Streptococcus sanguinis SK1 ?
-
?
IgA1 + H2O pH 7.2, 37°C Streptococcus sanguinis SK1 ?
-
?
IgA1 + H2O
-
Streptococcus sanguinis SK49 ?
-
?
IgA1 + H2O pH 7.2, 37°C Streptococcus sanguinis SK49 ?
-
?
IgA1 + H2O
-
Streptococcus mitis SK564 ?
-
?
IgA1 + H2O pH 7.2, 37°C Streptococcus mitis SK564 ?
-
?
IgA2-IgA1 half hinge + H2O a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 21% of the substrate is cleaved after 24 h incubation Neisseria meningitidis ?
-
?
IgA2-IgA1 half hinge + H2O a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 24% of the substrate is cleaved after 24 h incubation Haemophilus influenzae ?
-
?
IgA2-IgA1 half hinge + H2O a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 25% of the substrate is cleaved after 24 h incubation Streptococcus pneumoniae ?
-
?
IgA2-IgA1 half hinge + H2O a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 27% of the substrate is cleaved after 24 h incubation Haemophilus influenzae ?
-
?
IgA2-IgA1 half hinge + H2O a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 30% of the substrate is cleaved after 24 h incubation Streptococcus sanguinis ?
-
?
IgA2-IgA1 half hinge + H2O a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 4% of the substrate is cleaved after 24 h incubation Streptococcus sanguinis ?
-
?
IgA2-IgA1 half hinge + H2O a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 40% of the substrate is cleaved after 24 h incubation Neisseria meningitidis ?
-
?
IgA2-IgA1 half hinge + H2O a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 50% of the substrate is cleaved after 24 h incubation Neisseria gonorrhoeae ?
-
?
IgA2-IgA1 half hinge + H2O a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 85% of the substrate is cleaved after 24 h incubation Neisseria gonorrhoeae ?
-
?
IgA2-IgA1 half hinge + H2O a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 30% of the substrate is cleaved after 24 h incubation Streptococcus sanguinis SK4 ?
-
?
IgA2-IgA1 half hinge + H2O a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 25% of the substrate is cleaved after 24 h incubation Streptococcus pneumoniae SK690 ?
-
?
IgA2-IgA1 half hinge + H2O a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 30% of the substrate is cleaved after 24 h incubation Streptococcus sanguinis SK1 ?
-
?
IgA2-IgA1 half hinge + H2O a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 30% of the substrate is cleaved after 24 h incubation Streptococcus sanguinis SK49 ?
-
?
additional information no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S Streptococcus sanguinis ?
-
?
additional information no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S Streptococcus mitis ?
-
?
additional information no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S Streptococcus oralis ?
-
?
additional information no cleavage of mutant hhS230P Streptococcus sanguinis ?
-
?
additional information no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S Streptococcus mitis SK599 ?
-
?
additional information no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S Streptococcus mitis SK597 ?
-
?
additional information no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S Streptococcus oralis SK10 ?
-
?
additional information no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S Streptococcus sanguinis SK4 ?
-
?
additional information no cleavage of mutant hhS230P Streptococcus sanguinis SK4 ?
-
?
additional information no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S Streptococcus sanguinis SK1 ?
-
?
additional information no cleavage of mutant hhS230P Streptococcus sanguinis SK1 ?
-
?
additional information no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S Streptococcus sanguinis SK49 ?
-
?
additional information no cleavage of mutant hhS230P Streptococcus sanguinis SK49 ?
-
?
additional information no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S Streptococcus mitis SK564 ?
-
?
mutant hhP227S + H2O pH 7.2, 37°C, 29% of the substrate is cleaved after 24 h incubation Streptococcus sanguinis ?
-
?
mutant hhP227S + H2O pH 7.2, 37°C, 34% of the substrate is cleaved after 24 h incubation Streptococcus pneumoniae ?
-
?
mutant hhP227S + H2O pH 7.2, 37°C, 36% of the substrate is cleaved after 24 h incubation Haemophilus influenzae ?
-
?
mutant hhP227S + H2O pH 7.2, 37°C, 4% of the substrate is cleaved after 24 h incubation Streptococcus sanguinis ?
-
?
mutant hhP227S + H2O pH 7.2, 37°C, 54% of the substrate is cleaved after 24 h incubation Haemophilus influenzae ?
-
?
mutant hhP227S + H2O pH 7.2, 37°C, 62% of the substrate is cleaved after 24 h incubation Neisseria gonorrhoeae ?
-
?
mutant hhP227S + H2O pH 7.2, 37°C, 71% of the substrate is cleaved after 24 h incubation Neisseria gonorrhoeae ?
-
?
mutant hhP227S + H2O pH 7.2, 37°C, 78% of the substrate is cleaved after 24 h incubation Neisseria meningitidis ?
-
?
mutant hhP227S + H2O pH 7.2, 37°C, 81% of the substrate is cleaved after 24 h incubation Neisseria meningitidis ?
-
?
mutant hhP227S + H2O pH 7.2, 37°C, 34% of the substrate is cleaved after 24 h incubation Streptococcus pneumoniae SK690 ?
-
?
mutant hhS224/230P + H2O pH 7.2, 37°C, 17% of the substrate is cleaved after 24 h incubation Haemophilus influenzae ?
-
?
mutant hhS224/230P + H2O pH 7.2, 37°C, 19% of the substrate is cleaved after 24 h incubation Neisseria gonorrhoeae ?
-
?
mutant hhS224/230P + H2O pH 7.2, 37°C, 22% of the substrate is cleaved after 24 h incubation Neisseria gonorrhoeae ?
-
?
mutant hhS224/230P + H2O pH 7.2, 37°C, 25% of the substrate is cleaved after 24 h incubation Streptococcus sanguinis ?
-
?
mutant hhS224/230P + H2O pH 7.2, 37°C, 29% of the substrate is cleaved after 24 h incubation Streptococcus pneumoniae ?
-
?
mutant hhS224/230P + H2O pH 7.2, 37°C, 31% of the substrate is cleaved after 24 h incubation Streptococcus sanguinis ?
-
?
mutant hhS224/230P + H2O pH 7.2, 37°C, 35% of the substrate is cleaved after 24 h incubation Haemophilus influenzae ?
-
?
mutant hhS224/230P + H2O pH 7.2, 37°C, 4% of the substrate is cleaved after 24 h incubation Neisseria meningitidis ?
-
?
mutant hhS224/230P + H2O pH 7.2, 37°C, 7% of the substrate is cleaved after 24 h incubation Neisseria meningitidis ?
-
?
mutant hhS224/230P + H2O pH 7.2, 37°C, 29% of the substrate is cleaved after 24 h incubation Streptococcus pneumoniae SK690 ?
-
?
mutant hhS224P + H2O pH 7.2, 37°C, 19% of the substrate is cleaved after 24 h incubation Haemophilus influenzae ?
-
?
mutant hhS224P + H2O pH 7.2, 37°C, 20% of the substrate is cleaved after 24 h incubation Streptococcus sanguinis ?
-
?
mutant hhS224P + H2O pH 7.2, 37°C, 41% of the substrate is cleaved after 24 h incubation Neisseria gonorrhoeae ?
-
?
mutant hhS224P + H2O pH 7.2, 37°C, 49% of the substrate is cleaved after 24 h incubation Streptococcus sanguinis ?
-
?
mutant hhS224P + H2O pH 7.2, 37°C, 51% of the substrate is cleaved after 24 h incubation Neisseria gonorrhoeae ?
-
?
mutant hhS224P + H2O pH 7.2, 37°C, 58% of the substrate is cleaved after 24 h incubation Streptococcus pneumoniae ?
-
?
mutant hhS224P + H2O pH 7.2, 37°C, 67% of the substrate is cleaved after 24 h incubation Haemophilus influenzae ?
-
?
mutant hhS224P + H2O pH 7.2, 37°C, 70% of the substrate is cleaved after 24 h incubation Neisseria meningitidis ?
-
?
mutant hhS224P + H2O pH 7.2, 37°C, 74% of the substrate is cleaved after 24 h incubation Neisseria meningitidis ?
-
?
mutant hhS230P + H2O pH 7.2, 37°C, 13% of the substrate is cleaved after 24 h incubation Haemophilus influenzae ?
-
?
mutant hhS230P + H2O pH 7.2, 37°C, 13% of the substrate is cleaved after 24 h incubation Streptococcus sanguinis ?
-
?
mutant hhS230P + H2O pH 7.2, 37°C, 14% of the substrate is cleaved after 24 h incubation Haemophilus influenzae ?
-
?
mutant hhS230P + H2O pH 7.2, 37°C, 27% of the substrate is cleaved after 24 h incubation Streptococcus pneumoniae ?
-
?
mutant hhS230P + H2O pH 7.2, 37°C, 28% of the substrate is cleaved after 24 h incubation Neisseria gonorrhoeae ?
-
?
mutant hhS230P + H2O pH 7.2, 37°C, 3% of the substrate is cleaved after 24 h incubation Neisseria meningitidis ?
-
?
mutant hhS230P + H2O pH 7.2, 37°C, 7% of the substrate is cleaved after 24 h incubation Neisseria gonorrhoeae ?
-
?
mutant hhS230P + H2O pH 7.2, 37°C, 7% of the substrate is cleaved after 24 h incubation Neisseria meningitidis ?
-
?

Synonyms

Synonyms Comment Organism
IgA1 protease
-
Haemophilus influenzae
IgA1 protease
-
Neisseria gonorrhoeae
IgA1 protease
-
Neisseria meningitidis
IgA1 protease
-
Streptococcus pneumoniae
IgA1 protease
-
Streptococcus sanguinis
IgA1 protease
-
Streptococcus mitis
IgA1 protease
-
Streptococcus oralis