Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IgA1 + H2O | Haemophilus influenzae | - |
? | - |
? | |
IgA1 + H2O | Neisseria gonorrhoeae | - |
? | - |
? | |
IgA1 + H2O | Neisseria meningitidis | - |
? | - |
? | |
IgA1 + H2O | Streptococcus pneumoniae | - |
? | - |
? | |
IgA1 + H2O | Streptococcus sanguinis | - |
? | - |
? | |
IgA1 + H2O | Streptococcus mitis | - |
? | - |
? | |
IgA1 + H2O | Streptococcus oralis | - |
? | - |
? | |
IgA1 + H2O | Streptococcus mitis SK599 | - |
? | - |
? | |
IgA1 + H2O | Streptococcus mitis SK597 | - |
? | - |
? | |
IgA1 + H2O | Streptococcus oralis SK10 | - |
? | - |
? | |
IgA1 + H2O | Streptococcus sanguinis SK4 | - |
? | - |
? | |
IgA1 + H2O | Streptococcus pneumoniae SK690 | - |
? | - |
? | |
IgA1 + H2O | Streptococcus sanguinis SK1 | - |
? | - |
? | |
IgA1 + H2O | Streptococcus sanguinis SK49 | - |
? | - |
? | |
IgA1 + H2O | Streptococcus mitis SK564 | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemophilus influenzae | - |
H15 type 2 | - |
Haemophilus influenzae | - |
H23 type 1 | - |
Neisseria gonorrhoeae | - |
5489 type 2 | - |
Neisseria gonorrhoeae | - |
6092 type 1 | - |
Neisseria meningitidis | - |
HF13 type 2 | - |
Neisseria meningitidis | Q9K0B4 | 3564 type 1 | - |
Streptococcus mitis | - |
SK564 | - |
Streptococcus mitis | - |
SK597 | - |
Streptococcus mitis | - |
SK599 | - |
Streptococcus mitis SK564 | - |
SK564 | - |
Streptococcus mitis SK597 | - |
SK597 | - |
Streptococcus mitis SK599 | - |
SK599 | - |
Streptococcus oralis | - |
SK10 | - |
Streptococcus oralis SK10 | - |
SK10 | - |
Streptococcus pneumoniae | - |
SK690 | - |
Streptococcus pneumoniae SK690 | - |
SK690 | - |
Streptococcus sanguinis | - |
SK1 | - |
Streptococcus sanguinis | - |
SK4 | - |
Streptococcus sanguinis | - |
SK49 | - |
Streptococcus sanguinis SK1 | - |
SK1 | - |
Streptococcus sanguinis SK4 | - |
SK4 | - |
Streptococcus sanguinis SK49 | - |
SK49 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IgA1 + H2O | - |
Haemophilus influenzae | ? | - |
? | |
IgA1 + H2O | - |
Neisseria gonorrhoeae | ? | - |
? | |
IgA1 + H2O | - |
Neisseria meningitidis | ? | - |
? | |
IgA1 + H2O | - |
Streptococcus pneumoniae | ? | - |
? | |
IgA1 + H2O | - |
Streptococcus sanguinis | ? | - |
? | |
IgA1 + H2O | - |
Streptococcus mitis | ? | - |
? | |
IgA1 + H2O | - |
Streptococcus oralis | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Haemophilus influenzae | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Neisseria gonorrhoeae | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Neisseria meningitidis | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Streptococcus pneumoniae | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Streptococcus sanguinis | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Streptococcus mitis | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Streptococcus oralis | ? | - |
? | |
IgA1 + H2O | - |
Streptococcus mitis SK599 | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Streptococcus mitis SK599 | ? | - |
? | |
IgA1 + H2O | - |
Streptococcus mitis SK597 | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Streptococcus mitis SK597 | ? | - |
? | |
IgA1 + H2O | - |
Streptococcus oralis SK10 | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Streptococcus oralis SK10 | ? | - |
? | |
IgA1 + H2O | - |
Streptococcus sanguinis SK4 | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Streptococcus sanguinis SK4 | ? | - |
? | |
IgA1 + H2O | - |
Streptococcus pneumoniae SK690 | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Streptococcus pneumoniae SK690 | ? | - |
? | |
IgA1 + H2O | - |
Streptococcus sanguinis SK1 | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Streptococcus sanguinis SK1 | ? | - |
? | |
IgA1 + H2O | - |
Streptococcus sanguinis SK49 | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Streptococcus sanguinis SK49 | ? | - |
? | |
IgA1 + H2O | - |
Streptococcus mitis SK564 | ? | - |
? | |
IgA1 + H2O | pH 7.2, 37°C | Streptococcus mitis SK564 | ? | - |
? | |
IgA2-IgA1 half hinge + H2O | a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 21% of the substrate is cleaved after 24 h incubation | Neisseria meningitidis | ? | - |
? | |
IgA2-IgA1 half hinge + H2O | a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 24% of the substrate is cleaved after 24 h incubation | Haemophilus influenzae | ? | - |
? | |
IgA2-IgA1 half hinge + H2O | a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 25% of the substrate is cleaved after 24 h incubation | Streptococcus pneumoniae | ? | - |
? | |
IgA2-IgA1 half hinge + H2O | a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 27% of the substrate is cleaved after 24 h incubation | Haemophilus influenzae | ? | - |
? | |
IgA2-IgA1 half hinge + H2O | a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 30% of the substrate is cleaved after 24 h incubation | Streptococcus sanguinis | ? | - |
? | |
IgA2-IgA1 half hinge + H2O | a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 4% of the substrate is cleaved after 24 h incubation | Streptococcus sanguinis | ? | - |
? | |
IgA2-IgA1 half hinge + H2O | a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 40% of the substrate is cleaved after 24 h incubation | Neisseria meningitidis | ? | - |
? | |
IgA2-IgA1 half hinge + H2O | a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 50% of the substrate is cleaved after 24 h incubation | Neisseria gonorrhoeae | ? | - |
? | |
IgA2-IgA1 half hinge + H2O | a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 85% of the substrate is cleaved after 24 h incubation | Neisseria gonorrhoeae | ? | - |
? | |
IgA2-IgA1 half hinge + H2O | a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 30% of the substrate is cleaved after 24 h incubation | Streptococcus sanguinis SK4 | ? | - |
? | |
IgA2-IgA1 half hinge + H2O | a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 25% of the substrate is cleaved after 24 h incubation | Streptococcus pneumoniae SK690 | ? | - |
? | |
IgA2-IgA1 half hinge + H2O | a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 30% of the substrate is cleaved after 24 h incubation | Streptococcus sanguinis SK1 | ? | - |
? | |
IgA2-IgA1 half hinge + H2O | a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 30% of the substrate is cleaved after 24 h incubation | Streptococcus sanguinis SK49 | ? | - |
? | |
additional information | no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S | Streptococcus sanguinis | ? | - |
? | |
additional information | no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S | Streptococcus mitis | ? | - |
? | |
additional information | no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S | Streptococcus oralis | ? | - |
? | |
additional information | no cleavage of mutant hhS230P | Streptococcus sanguinis | ? | - |
? | |
additional information | no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S | Streptococcus mitis SK599 | ? | - |
? | |
additional information | no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S | Streptococcus mitis SK597 | ? | - |
? | |
additional information | no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S | Streptococcus oralis SK10 | ? | - |
? | |
additional information | no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S | Streptococcus sanguinis SK4 | ? | - |
? | |
additional information | no cleavage of mutant hhS230P | Streptococcus sanguinis SK4 | ? | - |
? | |
additional information | no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S | Streptococcus sanguinis SK1 | ? | - |
? | |
additional information | no cleavage of mutant hhS230P | Streptococcus sanguinis SK1 | ? | - |
? | |
additional information | no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S | Streptococcus sanguinis SK49 | ? | - |
? | |
additional information | no cleavage of mutant hhS230P | Streptococcus sanguinis SK49 | ? | - |
? | |
additional information | no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S | Streptococcus mitis SK564 | ? | - |
? | |
mutant hhP227S + H2O | pH 7.2, 37°C, 29% of the substrate is cleaved after 24 h incubation | Streptococcus sanguinis | ? | - |
? | |
mutant hhP227S + H2O | pH 7.2, 37°C, 34% of the substrate is cleaved after 24 h incubation | Streptococcus pneumoniae | ? | - |
? | |
mutant hhP227S + H2O | pH 7.2, 37°C, 36% of the substrate is cleaved after 24 h incubation | Haemophilus influenzae | ? | - |
? | |
mutant hhP227S + H2O | pH 7.2, 37°C, 4% of the substrate is cleaved after 24 h incubation | Streptococcus sanguinis | ? | - |
? | |
mutant hhP227S + H2O | pH 7.2, 37°C, 54% of the substrate is cleaved after 24 h incubation | Haemophilus influenzae | ? | - |
? | |
mutant hhP227S + H2O | pH 7.2, 37°C, 62% of the substrate is cleaved after 24 h incubation | Neisseria gonorrhoeae | ? | - |
? | |
mutant hhP227S + H2O | pH 7.2, 37°C, 71% of the substrate is cleaved after 24 h incubation | Neisseria gonorrhoeae | ? | - |
? | |
mutant hhP227S + H2O | pH 7.2, 37°C, 78% of the substrate is cleaved after 24 h incubation | Neisseria meningitidis | ? | - |
? | |
mutant hhP227S + H2O | pH 7.2, 37°C, 81% of the substrate is cleaved after 24 h incubation | Neisseria meningitidis | ? | - |
? | |
mutant hhP227S + H2O | pH 7.2, 37°C, 34% of the substrate is cleaved after 24 h incubation | Streptococcus pneumoniae SK690 | ? | - |
? | |
mutant hhS224/230P + H2O | pH 7.2, 37°C, 17% of the substrate is cleaved after 24 h incubation | Haemophilus influenzae | ? | - |
? | |
mutant hhS224/230P + H2O | pH 7.2, 37°C, 19% of the substrate is cleaved after 24 h incubation | Neisseria gonorrhoeae | ? | - |
? | |
mutant hhS224/230P + H2O | pH 7.2, 37°C, 22% of the substrate is cleaved after 24 h incubation | Neisseria gonorrhoeae | ? | - |
? | |
mutant hhS224/230P + H2O | pH 7.2, 37°C, 25% of the substrate is cleaved after 24 h incubation | Streptococcus sanguinis | ? | - |
? | |
mutant hhS224/230P + H2O | pH 7.2, 37°C, 29% of the substrate is cleaved after 24 h incubation | Streptococcus pneumoniae | ? | - |
? | |
mutant hhS224/230P + H2O | pH 7.2, 37°C, 31% of the substrate is cleaved after 24 h incubation | Streptococcus sanguinis | ? | - |
? | |
mutant hhS224/230P + H2O | pH 7.2, 37°C, 35% of the substrate is cleaved after 24 h incubation | Haemophilus influenzae | ? | - |
? | |
mutant hhS224/230P + H2O | pH 7.2, 37°C, 4% of the substrate is cleaved after 24 h incubation | Neisseria meningitidis | ? | - |
? | |
mutant hhS224/230P + H2O | pH 7.2, 37°C, 7% of the substrate is cleaved after 24 h incubation | Neisseria meningitidis | ? | - |
? | |
mutant hhS224/230P + H2O | pH 7.2, 37°C, 29% of the substrate is cleaved after 24 h incubation | Streptococcus pneumoniae SK690 | ? | - |
? | |
mutant hhS224P + H2O | pH 7.2, 37°C, 19% of the substrate is cleaved after 24 h incubation | Haemophilus influenzae | ? | - |
? | |
mutant hhS224P + H2O | pH 7.2, 37°C, 20% of the substrate is cleaved after 24 h incubation | Streptococcus sanguinis | ? | - |
? | |
mutant hhS224P + H2O | pH 7.2, 37°C, 41% of the substrate is cleaved after 24 h incubation | Neisseria gonorrhoeae | ? | - |
? | |
mutant hhS224P + H2O | pH 7.2, 37°C, 49% of the substrate is cleaved after 24 h incubation | Streptococcus sanguinis | ? | - |
? | |
mutant hhS224P + H2O | pH 7.2, 37°C, 51% of the substrate is cleaved after 24 h incubation | Neisseria gonorrhoeae | ? | - |
? | |
mutant hhS224P + H2O | pH 7.2, 37°C, 58% of the substrate is cleaved after 24 h incubation | Streptococcus pneumoniae | ? | - |
? | |
mutant hhS224P + H2O | pH 7.2, 37°C, 67% of the substrate is cleaved after 24 h incubation | Haemophilus influenzae | ? | - |
? | |
mutant hhS224P + H2O | pH 7.2, 37°C, 70% of the substrate is cleaved after 24 h incubation | Neisseria meningitidis | ? | - |
? | |
mutant hhS224P + H2O | pH 7.2, 37°C, 74% of the substrate is cleaved after 24 h incubation | Neisseria meningitidis | ? | - |
? | |
mutant hhS230P + H2O | pH 7.2, 37°C, 13% of the substrate is cleaved after 24 h incubation | Haemophilus influenzae | ? | - |
? | |
mutant hhS230P + H2O | pH 7.2, 37°C, 13% of the substrate is cleaved after 24 h incubation | Streptococcus sanguinis | ? | - |
? | |
mutant hhS230P + H2O | pH 7.2, 37°C, 14% of the substrate is cleaved after 24 h incubation | Haemophilus influenzae | ? | - |
? | |
mutant hhS230P + H2O | pH 7.2, 37°C, 27% of the substrate is cleaved after 24 h incubation | Streptococcus pneumoniae | ? | - |
? | |
mutant hhS230P + H2O | pH 7.2, 37°C, 28% of the substrate is cleaved after 24 h incubation | Neisseria gonorrhoeae | ? | - |
? | |
mutant hhS230P + H2O | pH 7.2, 37°C, 3% of the substrate is cleaved after 24 h incubation | Neisseria meningitidis | ? | - |
? | |
mutant hhS230P + H2O | pH 7.2, 37°C, 7% of the substrate is cleaved after 24 h incubation | Neisseria gonorrhoeae | ? | - |
? | |
mutant hhS230P + H2O | pH 7.2, 37°C, 7% of the substrate is cleaved after 24 h incubation | Neisseria meningitidis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IgA1 protease | - |
Haemophilus influenzae |
IgA1 protease | - |
Neisseria gonorrhoeae |
IgA1 protease | - |
Neisseria meningitidis |
IgA1 protease | - |
Streptococcus pneumoniae |
IgA1 protease | - |
Streptococcus sanguinis |
IgA1 protease | - |
Streptococcus mitis |
IgA1 protease | - |
Streptococcus oralis |