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Literature summary for 3.4.21.72 extracted from

  • Plaut, A.G.
    The IgA1 proteases of pathogenic bacteria (1983), Annu. Rev. Microbiol., 37, 603-622.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
Haemophilus influenzae gene Haemophilus influenzae
Haemophilus influenzae gene Neisseria gonorrhoeae
Neisseria gonorrhoeae gene in Escherichia coli Haemophilus influenzae
Neisseria gonorrhoeae gene in Escherichia coli Neisseria gonorrhoeae

Inhibitors

Inhibitors Comment Organism Structure
IgA secreted colostral IgA Neisseria gonorrhoeae
IgA secreted colostral IgA Neisseria meningitidis
IgA secreted colostral IgA Streptococcus sanguinis
Normal human serum
-
Neisseria gonorrhoeae
Normal human serum
-
Neisseria meningitidis

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Haemophilus influenzae
-
-
extracellular
-
Neisseria gonorrhoeae
-
-
extracellular
-
Neisseria meningitidis
-
-
extracellular
-
Streptococcus sanguinis
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
immunoglobulin A + H2O Haemophilus influenzae IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces ?
-
?
immunoglobulin A + H2O Neisseria gonorrhoeae IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces ?
-
?
immunoglobulin A + H2O Neisseria meningitidis IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces ?
-
?
immunoglobulin A + H2O Streptococcus sanguinis IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces ?
-
?

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
-
-
-
Neisseria gonorrhoeae
-
-
-
Neisseria meningitidis
-
-
-
Streptococcus sanguinis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture medium
-
Haemophilus influenzae
-
culture medium
-
Neisseria gonorrhoeae
-
culture medium
-
Neisseria meningitidis
-
culture medium
-
Streptococcus sanguinis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Immunoglobulin A + H2O all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant Haemophilus influenzae immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant Neisseria gonorrhoeae immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant Neisseria meningitidis immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant Streptococcus sanguinis immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge Haemophilus influenzae immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge Neisseria gonorrhoeae immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge Neisseria meningitidis immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge Streptococcus sanguinis immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O Haemophilus influenzae type 1 enzyme cleaves Pro231-Ser232, type 2 enzyme cleaves Pro235-Thr236, type 3 enzyme cleaves peptide bond 237-238 Haemophilus influenzae immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O peptide analogs of human IgA as protease substrates Haemophilus influenzae immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O peptide analogs of human IgA as protease substrates Neisseria gonorrhoeae immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O peptide analogs of human IgA as protease substrates Neisseria meningitidis immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O peptide analogs of human IgA as protease substrates Streptococcus sanguinis immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O Neisseria gonorrhoeae cleaves peptide bond 235-236 Neisseria gonorrhoeae immunoglobulin Fabalpha + immunoglobulin Fc
-
?
immunoglobulin A + H2O IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces Haemophilus influenzae ?
-
?
immunoglobulin A + H2O IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces Neisseria gonorrhoeae ?
-
?
immunoglobulin A + H2O IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces Neisseria meningitidis ?
-
?
immunoglobulin A + H2O IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces Streptococcus sanguinis ?
-
?