Cloned (Comment) | Organism |
---|---|
Haemophilus influenzae gene | Haemophilus influenzae |
Haemophilus influenzae gene | Neisseria gonorrhoeae |
Neisseria gonorrhoeae gene in Escherichia coli | Haemophilus influenzae |
Neisseria gonorrhoeae gene in Escherichia coli | Neisseria gonorrhoeae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
IgA | secreted colostral IgA | Neisseria gonorrhoeae | |
IgA | secreted colostral IgA | Neisseria meningitidis | |
IgA | secreted colostral IgA | Streptococcus sanguinis | |
Normal human serum | - |
Neisseria gonorrhoeae | |
Normal human serum | - |
Neisseria meningitidis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Haemophilus influenzae | - |
- |
extracellular | - |
Neisseria gonorrhoeae | - |
- |
extracellular | - |
Neisseria meningitidis | - |
- |
extracellular | - |
Streptococcus sanguinis | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
immunoglobulin A + H2O | Haemophilus influenzae | IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces | ? | - |
? | |
immunoglobulin A + H2O | Neisseria gonorrhoeae | IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces | ? | - |
? | |
immunoglobulin A + H2O | Neisseria meningitidis | IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces | ? | - |
? | |
immunoglobulin A + H2O | Streptococcus sanguinis | IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemophilus influenzae | - |
- |
- |
Neisseria gonorrhoeae | - |
- |
- |
Neisseria meningitidis | - |
- |
- |
Streptococcus sanguinis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
culture medium | - |
Haemophilus influenzae | - |
culture medium | - |
Neisseria gonorrhoeae | - |
culture medium | - |
Neisseria meningitidis | - |
culture medium | - |
Streptococcus sanguinis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Immunoglobulin A + H2O | all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant | Haemophilus influenzae | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
Immunoglobulin A + H2O | all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant | Neisseria gonorrhoeae | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
Immunoglobulin A + H2O | all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant | Neisseria meningitidis | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
Immunoglobulin A + H2O | all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant | Streptococcus sanguinis | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
Immunoglobulin A + H2O | Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge | Haemophilus influenzae | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
Immunoglobulin A + H2O | Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge | Neisseria gonorrhoeae | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
Immunoglobulin A + H2O | Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge | Neisseria meningitidis | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
Immunoglobulin A + H2O | Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge | Streptococcus sanguinis | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
Immunoglobulin A + H2O | Haemophilus influenzae type 1 enzyme cleaves Pro231-Ser232, type 2 enzyme cleaves Pro235-Thr236, type 3 enzyme cleaves peptide bond 237-238 | Haemophilus influenzae | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
Immunoglobulin A + H2O | peptide analogs of human IgA as protease substrates | Haemophilus influenzae | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
Immunoglobulin A + H2O | peptide analogs of human IgA as protease substrates | Neisseria gonorrhoeae | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
Immunoglobulin A + H2O | peptide analogs of human IgA as protease substrates | Neisseria meningitidis | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
Immunoglobulin A + H2O | peptide analogs of human IgA as protease substrates | Streptococcus sanguinis | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
Immunoglobulin A + H2O | Neisseria gonorrhoeae cleaves peptide bond 235-236 | Neisseria gonorrhoeae | immunoglobulin Fabalpha + immunoglobulin Fc | - |
? | |
immunoglobulin A + H2O | IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces | Haemophilus influenzae | ? | - |
? | |
immunoglobulin A + H2O | IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces | Neisseria gonorrhoeae | ? | - |
? | |
immunoglobulin A + H2O | IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces | Neisseria meningitidis | ? | - |
? | |
immunoglobulin A + H2O | IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces | Streptococcus sanguinis | ? | - |
? |