Activating Compound | Comment | Organism | Structure |
---|---|---|---|
kallikrein 5 | kallikrein 5 leads to an elastolytic activity increase of 4times compared with the basal activity level of pro-ELA2 | Mus musculus | |
kallikrein 5 | kallikrein 5 leads to an elastolytic activity increase of 4times compared with the basal activity level of pro-elastase 2 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
secretory leukoprotease inhibitor | - |
Homo sapiens | |
secretory leukoprotease inhibitor | - |
Mus musculus | |
skin-derived antileukoprotease | - |
Homo sapiens | |
skin-derived antileukoprotease | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(pro)-filaggrin + H2O | Mus musculus | direct degradation | ? | - |
? | |
(pro)-filaggrin + H2O | Homo sapiens | direct degradation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | localized to keratohyalin granules | Mus musculus | - |
epidermis | localized to keratohyalin granules | Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(pro)-filaggrin + H2O | direct degradation | Mus musculus | ? | - |
? | |
(pro)-filaggrin + H2O | direct degradation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ELA2 | - |
Mus musculus |
ELA2 | - |
Homo sapiens |
Elastase 2 | - |
Mus musculus |
Elastase 2 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000143 | - |
skin-derived antileukoprotease | pH and temperature not specified in the publication | Homo sapiens | |
0.0000299 | - |
secretory leukoprotease inhibitor | pH and temperature not specified in the publication | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | elastase 2 impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. The enzyme is a major protease driving the pathogenesis of Netherton syndrome | Homo sapiens |
physiological function | elastase 2 impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. The enzyme is a major protease driving the pathogenesis of Netherton syndrome. Transgenic elastase 2 mice display an ichthyotic phenotype | Mus musculus |