Literature summary for 3.4.21.7 extracted from

Brophy, T.M.; Ward, S.E.; McGimsey, T.R.; Schneppenheim, S.; Drakeford, C.; OSullivan, J.M.; Chion, A.; Budde, U.; ODonnell, J.S.
Plasmin cleaves von Willebrand factor at K1491-R1492 in the A1-A2 linker region in a shear- and glycan-dependent manner in vitro (2017), Arterioscler. Thromb. Vasc. Biol., 37, 845-855 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
von Willebrand factor + H2O	Homo sapiens	the enzyme cleaves von Willebrand factor at K1491-R149. Globular von Willebrand factor is resistant to plasmin cleavage under static conditions, but is readily cleaved by plasmin under shear	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
von Willebrand factor + H2O	the enzyme cleaves von Willebrand factor at K1491-R149. Globular von Willebrand factor is resistant to plasmin cleavage under static conditions, but is readily cleaved by plasmin under shear	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)