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Literature summary for 3.4.21.7 extracted from

  • Chung, M.C.; Tonry, J.H.; Narayanan, A.; Manes, N.P.; Mackie, R.S.; Gutting, B.; Mukherjee, D.V.; Popova, T.G.; Kashanchi, F.; Bailey, C.L.; Popov, S.G.
    Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity (2011), PLoS ONE, 6, e18119.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface plasminogen is a major surface-bound protein Homo sapiens 9986
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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General Information

General Information Comment Organism
additional information plasminogen is a major surface-bound protein interacting with pathogen Bacillus anthracis, it efficiently binds to spores of Bacillus anthracis in a lysine- and exosporium-dependent manner with alpha-enolase and elongation factor as specific receptors. Plasminogen-bound spores are capable of exhibiting anti-opsonic properties by cleaving C3b molecules in vitro and in rabbit bronchoalveolar lavage fluid, resulting in a decrease in macrophage phagocytosis. Mechanisms involved in the evasion of innate immunity by Bacillus anthracis through recruitment of plasminogen resulting in the enhancement of anti-complement and anti-opsonization properties of the pathogen, overview Homo sapiens