Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | Glu-plasminogen incubated with adherent cells, i.e. CHO-K1, HEK-293 and HMEC-1 cells, is converted into plasmin for activation by constitutively expressed tPA, i.e. tissue-type plasminogen activator, or uPA, i.e. urokinase-type plasminogen activator | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell membrane | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | Glu-plasminogen is cleaved to plasmin for activation by thrombin, as well as by constitutively expressed tPA, i.e. tissue-type plasminogen activator, or uPA, i.e. urokinase-type plasminogen activator | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | plasminogen incubated with adherent cells is converted into plasmin for activation by constitutively expressed tPA, i.e. tissue-type plasminogen activator, or uPA, i.e. urokinase-type plasminogen activator. Plasmin formed on the cell membrane then induces a unique response characterized by membrane blebbing and vesiculation. If plasmin formation persists, matrix proteins are then degraded, cells lose their attachments and enter the apoptotic process, characterized by DNA fragmentation and specific ultrastructural features. In plasminogen-treated cells, the nucleus shows chromatin condensation, the cytoplasm is disorganized, contains lysis vesicles and mitochondria become electron-dense | Homo sapiens |