Literature summary for 3.4.21.7 extracted from

Li, X.; Syrovets, T.; Genze, F.; Pitterle, K.; Oberhuber, A.; Orend, K.H.; Simmet, T.
Plasmin triggers chemotaxis of monocyte-derived dendritic cells through an Akt2-dependent pathway and promotes a T-helper type-1 response (2010), Arterioscler. Thromb. Vasc. Biol., 30, 582-590.

Search for more literature for 3.4.21.7

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
artery	vessel wall	Homo sapiens	-
monocyte	-	Homo sapiens	-
additional information	plasmin is abundant in human atherosclerotic lesions, where it colocalizes with dendritic cells	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	plasmin triggers chemotaxis of monocyte-derived dendritic cells through an Akt2-dependent pathway and promotes a T-helper type-1 response. Plasmin requires the annexin A2 heterotetramer for chemotactic signaling. Activation of Akt2 leads to extracellular signal-regulated kinase 1/2 activation and the chemotactic response. Plasmin elicits a time-dependent actin polymerization and triggers rapid activation of Akt and mitogen-activated protein kinases, followed by phosphorylation of the regulatory myosin light chain and chemotaxis. In dendritic cells, plasmin activates exclusively Akt2 via a p38 mitogen-activated protein kinase-dependent pathway, not Akt1 and Akt3. Plasmin-stimulated dendritic cells induce polarization of CD4+ T cells toward the interferon-gamma--producing, proinflammatory Th1 phenotype	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)