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Literature summary for 3.4.21.7 extracted from
- The interaction of Streptococcus pneumoniae with plasmin mediates transmigration across endothelial and epithelial monolayers by intercellular junction cleavage (2008), Infect. Immun., 76, 5350-5356.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in presence of plasmin on the bacterial surface, Streptococcus pneumoniae transmigration across epithelial A549 and endothelial EaHy layer increases | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
commercial product | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cadherin + H2O | plasmin bound to pneumococci is able to cleave recombinant vascular endothelial cadherin | Homo sapiens | ? | - |
? |  |
| additional information | adherence of plasmin-coated encapsulated or unencapsulated pneumococci induces sporadic disruption of EaHy or A549 monolayer cell junctions | Homo sapiens | ? | - |
? | |
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