Application | Comment | Organism |
---|---|---|
medicine | blocking plasmin prevents the generation of active platelet-derived growth factor-C, which is the major platelet-derived growth factor isoform relevant for proliferative vitreoretinopathy. Thus, plasmin is a therapeutic target for patients with proliferative vitreoretinopathy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha(2)-plasmin inhibitor | blocks plasmin activity | Homo sapiens | |
alpha(2)-plasmin inhibitor | blocks plasmin activity | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | - |
Homo sapiens | - |
eye | - |
Oryctolagus cuniculus | - |
serum | - |
Homo sapiens | - |
vitreous humor | normal eyes have a low, albeit detectable, level of plasmin. Levels of plasmin are higher in eyes from rabbits with proliferative vitreoretinopathy. Amounts correlate with the stage of proliferative vitreoretinopathy | Oryctolagus cuniculus | - |
vitreous humor | vitreous from patients with proliferative vitreoretinopathy have readily detectable levels of plasmin. Presence of plasmin is not unique to patients with proliferative vitreoretinopathy, but also present in a patient undergoing retinal surgery unrelated to proliferative vitreoretinopathy | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
platelet-derived growth factor-C + H2O | plasmin is the major protease responsible for processing platelet-derived growth factor-C in patients undergoing retinal surgery. Plasmin is vastly more potent (192times faster) than tissue plasminogen activator in processing the substrate | Homo sapiens | ? | - |
? | |
platelet-derived growth factor-C + H2O | plasmin is the major protease responsible for processing platelet-derived growth factor-C in rabbits with proliferative vitreoretinopathy | Oryctolagus cuniculus | ? | - |
? |