Application | Comment | Organism |
---|---|---|
medicine | less efficient proteolytic processing of the Pro370Leu protein by plasmin, coupled with the strong association of this variant with ethnicity, contributes to the differential prevalence of cardiovascular disease across ethnic groups | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
chromogranin A + H2O | chromogranin A-wild-type, chromogranin A-Gly364Ser and chromogranin A-Arg374Gln completely digested with plasmin at 0.0004 mM | Homo sapiens | catestatin + ? | - |
? | |
additional information | plasmin is 3-4fold less efficient in processing of the chromogranin A-Pro370Leu variant as compared to wild-type and the other varinats due to less efficient cleavage between Arg373-Arg374 | Homo sapiens | ? | - |
? |