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Literature summary for 3.4.21.7 extracted from

  • Kawao, N.; Okada, K.; Kawata, S.; Okamoto, C.; Tsuritani, M.; Ueshima, S.; Matsuo, O.
    Plasmin decreases the BH3-only protein BimEL via the ERK1/2 signaling pathway in hepatocytes (2007), Biochim. Biophys. Acta, 1773, 718-727.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Aprotinin augments binding of hepatocytes from mice to immobilized plasmin Homo sapiens

Application

Application Comment Organism
medicine the plasminogen/plasmin system decreases Bim(EL) expression and activation of caspase-3 via the ERK1/2 signaling pathway during liver regeneration, resulting in an enhancement of cell survival. Plasmin protects against starvation-induced apoptosis in primary hepatocytes of mice Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Aprotinin inhibits plasmin-induced phosphorylation of ERK1/2 Homo sapiens
diisopropyl fluorophosphate does not block binding of hepatocytes from mice to immobilized plasmin, but blocks active site of plasmin and its ability to phosphorylate ERK1/2 Homo sapiens
epsilon-aminocaproic acid inhibits plasmin-induced phosphorylation of ERK1/2; lysine binding sites inhibitor, partially blocks binding of hepatocytes from mice to immobilized plasmin at 10 mM, but not at 0.01 mM Homo sapiens
MG-132 prevents facilitation of degradation of Bim(EL) by plasmin in hepatocytes from mice pretreated with cycloheximide Homo sapiens
PD98059 MEK inhibitor, completely abolishes plasmin-induced phosphorylation of ERK1/2 at 0.05 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information plasmin triggeres phosphorylation of ERK1/2 in a concentration-dependent manner, but not of Akt Homo sapiens ?
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