Application | Comment | Organism |
---|---|---|
medicine | exerts proinflammatory functions. Direct activation of RAW264.7 cell monocytes by plasmin | synthetic construct |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-Val-Phe-Lys-chloromethyl ketone | inhibits the ability of plasmin to potentiate lipopolysaccharide signalling. Significantly inhibits the generation of TNFalpha from untransfected RAW cells after plasmin pretreatment and stimulated with LPS | synthetic construct | |
leupeptin | inhibits the ability of plasmin to potentiate lipopolysaccharide signalling | synthetic construct |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
synthetic construct | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | potentiates TLR2 and TLR4 signalling in RAW264.7 macrophages. Enhances endogenous production of TNFalpha and activation of an NF-kappaB reporter plasmid | synthetic construct | ? | - |
? | |
Suc-Ala-Phe-Lys-7-amido-4-methylcoumarin + H2O | - |
synthetic construct | ? | - |
? |