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BRENDA support

Literature summary for 3.4.21.7 extracted from

  • Ward, J.R.; Dower, S.K.; Whyte, M.K.; Buttle, D.J.; Sabroe, I.
    Potentiation of TLR4 signalling by plasmin activity (2006), Biochem. Biophys. Res. Commun., 341, 299-303.
    View publication on PubMed

Application

Application Comment Organism
medicine exerts proinflammatory functions. Direct activation of RAW264.7 cell monocytes by plasmin synthetic construct

Inhibitors

Inhibitors Comment Organism Structure
D-Val-Phe-Lys-chloromethyl ketone inhibits the ability of plasmin to potentiate lipopolysaccharide signalling. Significantly inhibits the generation of TNFalpha from untransfected RAW cells after plasmin pretreatment and stimulated with LPS synthetic construct
leupeptin inhibits the ability of plasmin to potentiate lipopolysaccharide signalling synthetic construct

Organism

Organism UniProt Comment Textmining
synthetic construct
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information potentiates TLR2 and TLR4 signalling in RAW264.7 macrophages. Enhances endogenous production of TNFalpha and activation of an NF-kappaB reporter plasmid synthetic construct ?
-
?
Suc-Ala-Phe-Lys-7-amido-4-methylcoumarin + H2O
-
synthetic construct ?
-
?