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Literature summary for 3.4.21.7 extracted from

  • Jiang, Q.; Taupenot, L.; Mahata, S.K.; Mahata, M.; O'Connor, D.T.; Miles, L.A.; Parmer, R.J.
    Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release (2001), J. Biol. Chem., 276, 25022-25029.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
chromogranin A + H2O Homo sapiens the product hCgA-(360-373) is a bioactive fragment that inhibits nicotinic-mediated catecholamine release. The plasminogen/plasmin system through its interaction with chromogranin A may play a major role in catecholaminergic function hCgA-(360-373) + ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chromogranin A + H2O
-
 Homo sapiens hCgA-(360-373) + ?
-
 ?
chromogranin A + H2O the product hCgA-(360-373) is a bioactive fragment that inhibits nicotinic-mediated catecholamine release. The plasminogen/plasmin system through its interaction with chromogranin A may play a major role in catecholaminergic function Homo sapiens hCgA-(360-373) + ?
-
 ?