Literature summary for 3.4.21.7 extracted from

Zhang, W.Y.; Ishii, I.; Kruth, H.S.
Plasmin-mediated macrophage reversal of low density lipoprotein aggregation (2000), J. Biol. Chem., 275, 33176-33183.

Search for more literature for 3.4.21.7

Inhibitors

Inhibitors	Comment	Organism	Structure
RG1192	dextran containing carboxymethylsulfate as well as benzylamide groups. Lysine-binding site domain of plasmin is the RG1192 binding site. In addition RG1192 blocks the generation of plasmin from Glu-plasminogen and inhibits the plasmin-mediated proteolysis of fibronectin and laminin	Homo sapiens
RG1503	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-Val-Leu-Lys-4-nitroanilide + H2O	-	Homo sapiens	D-Val-Leu-Lys + 4-nitroaniline	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000028	-	RG1192	pH 7.4, 37°C	Homo sapiens
0.00011	-	RG1503	pH 7.4, 37°C	Homo sapiens

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Release 2023.1 (January 2023)