Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.69 extracted from

  • Burnier, L.; Mosnier, L.O.
    Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3 (2013), Blood, 122, 807-816.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.69

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of the enzyme, co-expression with SEAP from a SEAP-protease activated receptor 3 fusion protein in HEK-293 cells with or without stable endothelial protein C receptor coexpression Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cleavage of protease activated receptor 3 zymogen by thrombin at Lys38 fails to induce PAR3-dependent intracellular signaling pathways but rather activates PAR1 and PAR2 ?
-
 ?
protease activated receptor 3 zymogen H2O Homo sapiens the enzyme cleaves the substrate PAR3 in transfected and endothelial cells in the presence of endothelial protein C receptor, as well as substrate mutant K38Q-PAR3, but fails to cleave the substrate mutant R41Q-PAR3 active protease activated receptor 3 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cleavage of protease activated receptor 3 zymogen by thrombin at Lys38 fails to induce PAR3-dependent intracellular signaling pathways but rather activates PAR1 and PAR2 Homo sapiens ?
-
 ?
protease activated receptor 3 N-terminal peptide + H2O the enzyme cleaves a synthetic PAR3 N-terminal peptide at Arg41 Homo sapiens ?
-
 ?
protease activated receptor 3 zymogen H2O the enzyme cleaves the substrate PAR3 in transfected and endothelial cells in the presence of endothelial protein C receptor, as well as substrate mutant K38Q-PAR3, but fails to cleave the substrate mutant R41Q-PAR3 Homo sapiens active protease activated receptor 3 + ?
-
 ?
protease activated receptor 3 zymogen H2O enzyme-mediated cleavage of PAR3 is analyzed by the proteolytic release of SEAP from a SEAP-PAR3 fusion protein expressed in HEK-293 cells in the absence or presence of stable endothelial protein C receptor coexpression Homo sapiens active protease activated receptor 3 + ?
-
 ?

Synonyms

Synonyms Comment Organism
Activated protein C
-
 Homo sapiens
APC
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function direct cytoprotective activities of activated protein C on cells convey therapeutic, relevant, beneficial effects in injury and require the endothelial protein C receptor and protease activated receptor 3, PAR3. In vivo, the enzyme-derived PAR3 tethered-ligand peptide, but not the thrombin-derived PAR3 peptide, blunts vascular endothelial growth factor-induced vascular permeability Homo sapiens