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Literature summary for 3.4.21.69 extracted from

  • Hemmer, C.J.; Loebermann, M.; Unverricht, M.; Vogt, A.; Krause, R.; Reisinger, E.C.
    Activated protein C protects vascular endothelial cells from apoptosis in malaria and in sepsis (2011), Trop. Med. Int. Health, 16, 906-913.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
Activated protein C
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 Homo sapiens

General Information

General Information Comment Organism
physiological function activated protein C has anti-apoptotic effects and improves survival in sepsis, activated protein C prevents endothelial cell apoptosis, induced by serum from patients with malaria or sepsis. Activated protein C alone lowers the endothelial cell apoptosis rate from 48% to 38% in the presence of patient serum, In combination with ascorbic acid, activated protein C lowers the apoptosis rate to 25% and in combination with ulinastatin to 23% Homo sapiens