Any feedback?
Literature summary for 3.4.21.69 extracted from
- Down regulation of prothrombinase by activated protein C during prothrombin activation (2010), Thromb. Haemost., 104, 61-70.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| protein S | the protein S effect is aPC-dependent | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics of FVa inactivation by aPC | Homo sapiens | |
| 0.0000197 | - |
Factor Va | pH 7.4, 22°C | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Factor Va + H2O | Homo sapiens | cleavage at Arg306, Arg506, and Arg679 of the heavy chain | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Factor Va + H2O | cleavage at Arg306, Arg506, and Arg679 of the heavy chain | Homo sapiens | ? | - |
? | |
| Factor Va + H2O | cleavage at Arg306, Arg506, and Arg679 of the heavy chain. FVa is protected by prothrombin about 7.6fold in the absence of FXa | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Activated protein C | - |
Homo sapiens |
| APC | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.395 | - |
Factor Va | pH 7.4, 22°C | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | activated protein C is a serine protease that downregulates coagulation by proteolytically inactivating cofactors FVa and factor VIIIa, activated protein C proteolytically inactivates factor Va and thereby down regulates prothrombinase. Prothrombinase is inactivated by aPC during prothrombin activation much more slowly than Factor Va is inactivated in the absence of Factor Xa and prothrombin | Homo sapiens |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 20000 | - |
Factor Va | pH 7.4, 22°C | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
