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Literature summary for 3.4.21.69 extracted from

  • Toltl, L.J.; Austin, R.C.; Liaw, P.C.
    Activated protein C modulates inflammation, apoptosis and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes (2011), J. Thromb. Haemost., 9, 582-592.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant enzyme Homo sapiens
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monocyte
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
Activated protein C
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 Homo sapiens
APC
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 Homo sapiens

General Information

General Information Comment Organism
physiological function activated protein C modulates inflammation, apoptosis and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes. Protective effects of APC treatment in severe sepsis. APC decreases phosphorylated eukaryotic translational initiation factor 2alpha and C/EBP homologous protein levels induced by thapsigargin. APC inhibits thapsigargin-induced ER Ca2+ flux and reactive oxygen species generation. Functionally, APC diminishes thapsigargin-induced caspase-3 activity and degradation of the nuclear factor kappaB inhibitor IkappaBalpha. Furthermore, APC dampens the induction of tissue factor procoagulant activity facilitated by thapsigargin, and APC dampens unfolded protein response activation Homo sapiens