Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | APC upregulates TNF receptor-associated factor 2, TRAF2, and phosphorylates NF-kappaB p65 at Ser276 and Ser536 independently of IkappaB degradation, real-time quantitative PCR analysis, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant APC | Homo sapiens | - |
vascular endothelial cell | HUVEC | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | APC upregulates TNF receptor-associated factor 2, TRAF2, and phosphorylates NF-kappaB p65 at Ser276 and Ser536 independently of IkappaB degradation, real-time quantitative PCR analysis, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | activated protein C is a natural anticoagulant protease that displays cytoprotective and antiinflammatory activities and has been demonstrated to reduce mortality of patients with severe sepsis. Protective cross talk between activated protein C and TNF signaling in vascular endothelial cells, overview. APC signaling causes a moderate but significant induction of cell adhesion molecules including VCAM-1 at mRNA and protein levels. Activation of the noncanonical NF-kappaB and ERK1/2 are both pivotal to APC signaling leading to VCAM-1 expression, PAR1 and EPCR equally mediate APC signaling that triggers VCAM-1 expression. APC upregulates TNF receptor-associated factor 2, TRAF2, and phosphorylates NF-kappaB p65 at Ser276 and Ser536 independently of IkappaB degradation, and it shows a regulatory effect on VCAM-1 expression, detailed overview. Ability of APC to activate ERK1/2 in resting cells and to enhance ERK activation in TNF-treated cells, activated ERK1/2 MAPK serves as an antiinflammatory signal in endothelial cells | Homo sapiens |