Literature summary for 3.4.21.69 extracted from

Takeyama, M.; Nogami, K.; Saenko, E.L.; Soeda, T.; Nishiya, K.; Ogiwara, K.; Yoshioka, A.; Shima, M.
Protein S down-regulates factor Xase activity independent of activated protein C: specific binding of factor VIII(a) to protein S inhibits interactions with factor IXa (2008), Br. J. Haematol., 143, 409-420.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
Activated protein C	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
additional information	protein S not only down-regulates factor VIIIa activity as a cofactor of activated protein C, but also directly impairs the assembly of the factor Xase complex, independent of activated protein C, in a competitive interaction between factor IXa and factor VIIIa	Homo sapiens

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Release 2023.1 (January 2023)