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Literature summary for 3.4.21.69 extracted from

  • Cheng, T.; Petraglia, A.L.; Li, Z.; Thiyagarajan, M.; Zhong, Z.; Wu, Z.; Liu, D.; Maggirwar, S.B.; Deane, R.; Fernandez, J.A.; LaRue, B.; Griffin, J.H.; Chopp, M.; Zlokovic, B.V.
    Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage (2006), Nat. Med., 12, 1278-1285.
    View publication on PubMed
Search for more literature for 3.4.21.69

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens activated protein C is a plasma serine protease with systemic anticoagulant, anti-inflammatory and antiapoptotic activities, and direct vasculoprotective and neuroprotective activities, it blocks tissue plasminogen activator-mediated brain hemorrhage after transient brain ischemia and embolic stroke in mice, overview, APC inhibits a pro-hemorrhagic tissue plasminogen activator-induced, NF-kappaB-dependent matrix metalloproteinase-9 pathway in ischemic brain endothelium in vivo and in vitro by acting through protease-activated receptor 1, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activated protein C is a plasma serine protease with systemic anticoagulant, anti-inflammatory and antiapoptotic activities, and direct vasculoprotective and neuroprotective activities, it blocks tissue plasminogen activator-mediated brain hemorrhage after transient brain ischemia and embolic stroke in mice, overview, APC inhibits a pro-hemorrhagic tissue plasminogen activator-induced, NF-kappaB-dependent matrix metalloproteinase-9 pathway in ischemic brain endothelium in vivo and in vitro by acting through protease-activated receptor 1, overview Homo sapiens ?
-
 ?
additional information APC inhibits a pro-hemorrhagic tissue plasminogen activator-induced, NF-kappaB-dependent matrix metalloproteinase-9 pathway in ischemic brain endothelium in vivo and in vitro by acting through protease-activated receptor 1 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Activated protein C
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 Homo sapiens
APC
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 Homo sapiens