Protein Variants | Comment | Organism |
---|---|---|
S360A | site-directed mutagenesis, catalytic site residue mutation, mutant thrombin W215A/E217A induces protective signaling only in the presence of wild type protein C but not mutant protein C S360A | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | wild-type inactive protein C and inactive protein C mutant S360A inhibit the binding of activated protein C to the endothelial protein C receptor | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | the activated protein C occurs at the cell surfaceof endothelial cells | Homo sapiens | 9986 | - |
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | activated protein C has endothelial barrier protective effects that require binding to endothelial protein C receptor, EPCR, and cleavage of protease activated receptor-1, PAR1, and that may play a role in the anti-inflammatory action of APC, thrombin does not exert directly barrier protective effects, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | protein C zymogen activation by thrombin on the endothelial cell surface, the double mutant thrombin W215A/E217A is also active in protein C activation and produces APC with high barrier protective activity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | APC from plasma | Homo sapiens | - |
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | activated protein C has endothelial barrier protective effects that require binding to endothelial protein C receptor, EPCR, and cleavage of protease activated receptor-1, PAR1, and that may play a role in the anti-inflammatory action of APC, thrombin does not exert directly barrier protective effects, overview | Homo sapiens | ? | - |
? | |
S-2366 + H2O | synthetic substrate for amidolytic activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Homo sapiens |