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Literature summary for 3.4.21.69 extracted from
- Recombinant human activated protein C (2006), Int. J. Antimicrob. Agents, 28, 90-94.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | activated protein C might be useful as therapeutic agent in sepsis, clinical trials, overview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | protein C has antiinflammatory, anticoagulant and pro-fibrinolytic activities in humans, counteracting some of the main pro-inflammatory pathophysiological mechanisms in sepsis, overview, the antithrombotic effect is caused by irreversible inactivation of factors Va and VIIIa, the anti-inflammatory activity reduces formation of TNF, IL-8, IL-6 and thrombin and limits the rolling of monocytes and neutrophils on injured endothelium by binding selectins, it may reduce apoptosis, the pro-fibrinolytic activity occurs due to inhibition of PAI-1 and indirectly via reduced thrombin and thrombin-activatable fibrinolysis inhibitor | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | protein C has antiinflammatory, anticoagulant and pro-fibrinolytic activities in humans, counteracting some of the main pro-inflammatory pathophysiological mechanisms in sepsis, overview, the antithrombotic effect is caused by irreversible inactivation of factors Va and VIIIa, the anti-inflammatory activity reduces formation of TNF, IL-8, IL-6 and thrombin and limits the rolling of monocytes and neutrophils on injured endothelium by binding selectins, it may reduce apoptosis, the pro-fibrinolytic activity occurs due to inhibition of PAI-1 and indirectly via reduced thrombin and thrombin-activatable fibrinolysis inhibitor | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Activated protein C | - |
Homo sapiens |
| APC | - |
Homo sapiens |
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