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Literature summary for 3.4.21.69 extracted from
- Activated protein C: controversy and hope in the treatment of sepsis (2007), Curr. Opin. Investig. Drugs, 8, 933-938.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme is used for treatment of sepsis in humans, but the enzyme shows harmful side effects by causing life-threatening hemorrhage, clinical trials, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme shows anticoagulation activity and can prolonge life of sepsis patients, but can also cause hemorrhage, mechanism of action and biological effects, detailed overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | activated protein C | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme shows anticoagulation activity and can prolonge life of sepsis patients, but can also cause hemorrhage, mechanism of action and biological effects, detailed overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Activated protein C | - |
Homo sapiens |
| APC | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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