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Literature summary for 3.4.21.69 extracted from

  • Maurissen, L.F.; Thomassen, M.C.; Nicolaes, G.A.; Dahlbaeck, B.; Tans, G.; Rosing, J.; Hackeng, T.M.
    Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation (2008), Blood, 111, 3034-3041.
    View publication on PubMed
Search for more literature for 3.4.21.69

Activating Compound

Activating Compound Comment Organism Structure
protein S the cofactor is active as free protein and in complex with C4b binding protein, the latter shows a less potent effect, activation up to 10fold, but the complex inhibits proteolysis at Arg506 by 3-4fold, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Phe-Pro-Arg-chloromethylketone
-
 Homo sapiens
protein S the cofactor is active as free protein and in complex with C4b binding protein, the latter shows a less potent effect, activation up to 10fold, but the complex inhibits proteolysis at Arg506 by 3-4fold, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
active factor Va + H2O Homo sapiens proteolytic inactivation inactive factor V + domain B
-
 ?
additional information Homo sapiens activated protein C acts as feedback inhibitor of thrombin production ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the protein C zymogen is activated by thrombin Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
active factor Va + H2O proteolytic inactivation Homo sapiens inactive factor V + domain B
-
 ?
active factor Va + H2O proteolytic inactivation, cleavage at Arg306 and Arg506 Homo sapiens inactive factor V + domain B
-
 ?
additional information activated protein C acts as feedback inhibitor of thrombin production Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.7
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
protein S the cofactor is active as free protein and in complex with C4b binding protein, the latter shows a less potent effect, activation up to 10fold, but the complex inhibits proteolysis at Arg506 by 3-4fold, overview Homo sapiens