Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K37S/K38Q/K39Q | created by site-directed in vitro mutagenesis | Homo sapiens |
K37S/K38Q/K39Q/K62N/K63D | created by site-directed in vitro mutagenesis | Homo sapiens |
R74Q | created by site-directed in vitro mutagenesis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
protein C inhibitor PCI | inhibition stimulated by heparin | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0009 | - |
S-2366 | pH 7.4, 37°C, mutant R74Q | Homo sapiens | |
0.00091 | - |
S-2366 | pH 7.4, 37°C, wild type | Homo sapiens | |
0.00093 | - |
S-2366 | pH 7.4, 37°C, mutant K37S/K38Q/K39Q/K62N/K63D | Homo sapiens | |
0.00095 | - |
S-2366 | pH 7.4, 37°C, mutant K62N/K63D | Homo sapiens | |
0.00098 | - |
S-2366 | pH 7.4, 37°C, mutant K37S/K38Q/K39Q | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor Va + H2O | Homo sapiens | natural anticoagulant, inhibits thrombin generation by degrading factors Va and VIIIa | ? | - |
? | |
Factor VIIIa + H2O | Homo sapiens | natural anticoagulant, inhibits thrombin generation by degrading factors Va and VIIIa | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Factor Va + H2O | natural anticoagulant, inhibits thrombin generation by degrading factors Va and VIIIa | Homo sapiens | ? | - |
? | |
Factor VIIIa + H2O | natural anticoagulant, inhibits thrombin generation by degrading factors Va and VIIIa | Homo sapiens | ? | - |
? | |
S-2366 + H2O | i.e. 5-oxo-L-Pro-L-Pro-L-Arg-p-anitroanilide | Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
70 | - |
S-2366 | pH 7.4, 37°C, wild type | Homo sapiens | |
71 | - |
S-2366 | pH 7.4, 37°C, mutant K37S/K38Q/K39Q/K62N/K63D | Homo sapiens | |
75 | - |
S-2366 | pH 7.4, 37°C, mutant K37S/K38Q/K39Q | Homo sapiens | |
76 | - |
S-2366 | pH 7.4, 37°C, mutant R74Q | Homo sapiens | |
78 | - |
S-2366 | pH 7.4, 37°C, mutant K62N/K63D | Homo sapiens |