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Literature summary for 3.4.21.62 extracted from

  • Armistead, J.S.; Jennison, C.; O'Neill, M.T.; Lopaticki, S.; Liehl, P.; Hanson, K.K.; Annoura, T.; Rajasekaran, P.; Erickson, S.M.; Tonkin, C.J.; Khan, S.M.; Mota, M.M.; Boddey, J.A.
    Plasmodium falciparum subtilisin-like ookinete protein SOPT plays an important and conserved role during ookinete infection of the Anopheles stephensi midgut (2018), Mol. Microbiol., 109, 458-473 .
    View publication on PubMed
Search for more literature for 3.4.21.62

Cloned(Commentary)

Cloned (Comment) Organism
gene PBANKA_1106900, genetic structure, sequence comparisons Plasmodium berghei
gene PF3D7_0507300, genetic structure, sequence comparisons Plasmodium falciparum

Protein Variants

Protein Variants Comment Organism
additional information generation of enzyme-deficient mutant PbDELTASOPT/PIMMS2, production of oocysts and sporozoites in mosquitoes containing PbDELTASOPT/PIMMS2 parasites Plasmodium berghei

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information enzyme SOPT contains a signal peptide Plasmodium falciparum
-
-
additional information enzyme SOPT contains a signal peptide Plasmodium berghei
-
-

Organism

Organism UniProt Comment Textmining
Plasmodium berghei A0A509AKI1
-
-
Plasmodium berghei ANKA A0A509AKI1
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-
Plasmodium falciparum Q8I429
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-

Source Tissue

Source Tissue Comment Organism Textmining
ookinete the enzyme is expressed in asexual, ookinete and sporozoite stages. SOPT is not exported to the erythrocyte but is expressed in ookinetes at the parasite periphery Plasmodium falciparum
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ookinete the enzyme is expressed in asexual, ookinete and sporozoite stages. SOPT is not exported to the erythrocyte but is expressed in ookinetes at the parasite periphery Plasmodium berghei
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Synonyms

Synonyms Comment Organism
PBANKA_1106900
-
 Plasmodium berghei
PbSOPT
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 Plasmodium berghei
PF3D7_0507300
-
 Plasmodium falciparum
PIMMS2
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 Plasmodium berghei
SOPT
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 Plasmodium falciparum
SOPT
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 Plasmodium berghei
subtilisin-like ookinete protein
-
 Plasmodium falciparum
subtilisin-like ookinete protein
-
 Plasmodium berghei
subtilisin-like ookinete protein important for transmission
-
 Plasmodium falciparum
subtilisin-like ookinete protein important for transmission
-
 Plasmodium berghei

General Information

General Information Comment Organism
evolution enzyme SOPT has a PEXEL-like sequence, is predicted to contain a subtilisin-like fold with a non-canonical catalytic triad, and is orthologous to Plasmodium falciparum SOPT. The function of SOPT is conserved in different Plasmodium species, overview Plasmodium berghei
evolution enzyme SOPT has a PEXEL-like sequence, it is predicted to contain a subtilisin-like fold with a non-canonical catalytic triad, and it is orthologous to Plasmodium berghei PIMMS2. The function of SOPT is conserved in different Plasmodium species, overview Plasmodium falciparum
malfunction SOPT-deficient parasites develop normally through the asexual and sexual stages and produce equivalent numbers of ookinetes to NF54 controls, but they form fewer oocysts and sporozoites in mosquitoes Plasmodium falciparum
malfunction the mutant PbDELTASOPT/PIMMS2 produces low numbers of salivary gland sporozoites Plasmodium berghei
additional information homology modeling of Plasmodium berghei SOPT, overview Plasmodium berghei
additional information homology modeling of Plasmodium falciparum SOPT, overview Plasmodium falciparum
physiological function Plasmodium berghei PbSOPT/PIMMS2 is dispensable for ookinete development, and PbSOPT/PIMMS2 is dispensable for sporozoite infectivity and establishing patency. PIMMS2 is involved in midgut traversal in Anopheles gambiae. SOPT facilitates transmission of Plasmodium berghei ookinetes to mosquitoes Plasmodium berghei
physiological function Plasmodium falciparum subtilisin-like ookinete protein SOPT plays an important and conserved role during ookinete infection of the Anopheles stephensi midgut. It may be involved in infecting the human or mosquito host. SOPT facilitates transmission of Plasmodium falciparum ookinetes to mosquitoes Plasmodium falciparum