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Literature summary for 3.4.21.62 extracted from

  • Pietrusewicz, E.; Sienczyk, M.; Oleksyszyn, J.
    Novel diphenyl esters of peptidyl alpha-aminoalkylphosphonates as inhibitors of chymotrypsin and subtilisin (2009), J. Enzyme Inhib. Med. Chem., 24, 1229-1236.
    View publication on PubMed
Search for more literature for 3.4.21.62

Inhibitors

Inhibitors Comment Organism Structure
2,2'-[[(1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphoryl]bis(oxybenzene-4,1-diyl)]diacetic acid
-
 Bacillus licheniformis
2,2'-[[(1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphoryl]bis(oxybenzene-4,1-diyl)]diacetic acid
-
 Bacillus licheniformis
2,2'-[[(1-[[1-(tert-butoxycarbonyl)-L-prolyl]amino]-3-methylbutyl)phosphoryl]bis(oxybenzene-3,1-diyl)]diacetic acid
-
 Bacillus licheniformis
bis(2,3,5-trimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
bis(2,3-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate
-
 Bacillus licheniformis
bis(2,3-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
bis(2,5-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
bis(2-methylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate
-
 Bacillus licheniformis
bis(2-methylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
bis(3,4,5-trimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate
-
 Bacillus licheniformis
bis(3,4,5-trimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
bis(3,4-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate
-
 Bacillus licheniformis
bis(3,4-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
bis(3-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate
-
 Bacillus licheniformis
bis(3-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
bis(3-methoxyphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
bis(4-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate
-
 Bacillus licheniformis
bis(4-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate
-
 Bacillus licheniformis
bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
bis(4-methoxyphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate
-
 Bacillus licheniformis
bis(4-methylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
bis(4-tert-butylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate
-
 Bacillus licheniformis
bis(4-tert-butylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
bis[4-(methylsulfonyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate
-
 Bacillus licheniformis
bis[4-(propan-2-yl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate
-
 Bacillus licheniformis
bis[4-(propan-2-yl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
bis[4-(sulfanylmethyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate
-
 Bacillus licheniformis
bis[4-(sulfanylmethyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
diphenyl (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate
-
 Bacillus licheniformis
diphenyl (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate
-
 Bacillus licheniformis
N-(tert-butoxycarbonyl)-L-valyl-N-(1-[bis[4-(sulfanylmethyl)phenoxy]phosphoryl]-2-phenylethyl)-L-prolinamide
-
 Bacillus licheniformis
N-(tert-butoxycarbonyl)-L-valyl-N-[1-(diphenoxyphosphoryl)-2-phenylethyl]-L-prolinamide
-
 Bacillus licheniformis
N-(tert-butoxycarbonyl)-L-valyl-N-[1-[bis(3,4,5-trimethylphenoxy)phosphoryl]-3-methylbutyl]-L-prolinamide
-
 Bacillus licheniformis
N-(tert-butoxycarbonyl)-L-valyl-N-[1-[bis(4-methoxyphenoxy)phosphoryl]-3-methylbutyl]-L-prolinamide
-
 Bacillus licheniformis
N-(tert-butoxycarbonyl)-L-valyl-N-[1-[bis(4-tert-butylphenoxy)phosphoryl]-3-methylbutyl]-L-prolinamide
-
 Bacillus licheniformis
Suc-Val-Pro-PheP(OPh)2
-
 Bacillus licheniformis
tert-butyl (2S)-2-([1-[bis(2-methylphenoxy)phosphoryl]-3-methylbutyl]carbamoyl)pyrrolidine-1-carboxylate
-
 Bacillus licheniformis
tert-butyl (2S)-2-([1-[bis(3,4,5-trimethylphenoxy)phosphoryl]-3-methylbutyl]carbamoyl)pyrrolidine-1-carboxylate
-
 Bacillus licheniformis
tert-butyl (2S)-2-([1-[bis(3,4-dimethylphenoxy)phosphoryl]-3-methylbutyl]carbamoyl)pyrrolidine-1-carboxylate
-
 Bacillus licheniformis
tert-butyl (2S)-2-([1-[bis(4-methoxyphenoxy)phosphoryl]-3-methylbutyl]carbamoyl)pyrrolidine-1-carboxylate
-
 Bacillus licheniformis
tert-butyl (2S)-2-([1-[bis(4-methylphenoxy)phosphoryl]-3-methylbutyl]carbamoyl)pyrrolidine-1-carboxylate
-
 Bacillus licheniformis
tert-butyl (2S)-2-[(1-[bis[4-(sulfanylmethyl)phenoxy]phosphoryl]-2-phenylethyl)carbamoyl]pyrrolidine-1-carboxylate
-
 Bacillus licheniformis
tert-butyl (2S)-2-[[1-(diphenoxyphosphoryl)-2-phenylethyl]carbamoyl]pyrrolidine-1-carboxylate
-
 Bacillus licheniformis

Organism

Organism UniProt Comment Textmining
Bacillus licheniformis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-Ala-Ala-Pro-Phe-7-amido-4-methylcoumarin + H2O
-
 Bacillus licheniformis succinyl-Ala-Ala-Pro-Phe + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
subtilisin A
-
 Bacillus licheniformis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00006
-
 N-(tert-butoxycarbonyl)-L-valyl-N-[1-[bis(4-methoxyphenoxy)phosphoryl]-3-methylbutyl]-L-prolinamide in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.000076
-
 bis[4-(methylsulfonyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.000093
-
 N-(tert-butoxycarbonyl)-L-valyl-N-(1-[bis[4-(sulfanylmethyl)phenoxy]phosphoryl]-2-phenylethyl)-L-prolinamide in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.00023
-
 N-(tert-butoxycarbonyl)-L-valyl-N-[1-(diphenoxyphosphoryl)-2-phenylethyl]-L-prolinamide in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.00135
-
 2,2'-[[(1-[[1-(tert-butoxycarbonyl)-L-prolyl]amino]-3-methylbutyl)phosphoryl]bis(oxybenzene-3,1-diyl)]diacetic acid in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.00206
-
 Suc-Val-Pro-PheP(OPh)2 in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.00213
-
 bis[4-(sulfanylmethyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.00228
-
 tert-butyl (2S)-2-([1-[bis(4-methylphenoxy)phosphoryl]-3-methylbutyl]carbamoyl)pyrrolidine-1-carboxylate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.00274
-
 2,2'-[[(1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphoryl]bis(oxybenzene-4,1-diyl)]diacetic acid in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.0053
-
 tert-butyl (2S)-2-[(1-[bis[4-(sulfanylmethyl)phenoxy]phosphoryl]-2-phenylethyl)carbamoyl]pyrrolidine-1-carboxylate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.00637
-
 diphenyl (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.00705
-
 tert-butyl (2S)-2-([1-[bis(4-methoxyphenoxy)phosphoryl]-3-methylbutyl]carbamoyl)pyrrolidine-1-carboxylate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.00792
-
 bis(4-tert-butylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.0121
-
 tert-butyl (2S)-2-[[1-(diphenoxyphosphoryl)-2-phenylethyl]carbamoyl]pyrrolidine-1-carboxylate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(2-methylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(4-methoxyphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis[4-(propan-2-yl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(4-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(2,3-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(4-tert-butylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(3,4-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(3-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(3,4,5-trimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 tert-butyl (2S)-2-([1-[bis(3,4,5-trimethylphenoxy)phosphoryl]-3-methylbutyl]carbamoyl)pyrrolidine-1-carboxylate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 tert-butyl (2S)-2-([1-[bis(2-methylphenoxy)phosphoryl]-3-methylbutyl]carbamoyl)pyrrolidine-1-carboxylate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 N-(tert-butoxycarbonyl)-L-valyl-N-[1-[bis(3,4,5-trimethylphenoxy)phosphoryl]-3-methylbutyl]-L-prolinamide in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 N-(tert-butoxycarbonyl)-L-valyl-N-[1-[bis(4-tert-butylphenoxy)phosphoryl]-3-methylbutyl]-L-prolinamide in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(2,3,5-trimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(3,4,5-trimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis[4-(propan-2-yl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(3,4-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(4-methylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(2,3-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(2-methylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(4-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(3-chlorophenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 diphenyl (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis[4-(sulfanylmethyl)phenyl] (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(2,5-dimethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 2,2'-[[(1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphoryl]bis(oxybenzene-4,1-diyl)]diacetic acid in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(3-methoxyphenyl) (1-[[(benzyloxy)carbonyl]amino]-3-methylbutyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.02
-
 bis(4-ethylphenyl) (1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)phosphonate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis
0.036
-
 tert-butyl (2S)-2-([1-[bis(3,4-dimethylphenoxy)phosphoryl]-3-methylbutyl]carbamoyl)pyrrolidine-1-carboxylate in 50 mM Tris, 1M NaCl, pH 7.5 containing 0.01% Triton X-100 Bacillus licheniformis