Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.61 extracted from

  • Wang, P.; Wang, F.; Wang, L.; Pan, J.
    Proprotein convertase subtilisin/kexin type 6 activates the extracellular signal-regulated kinase 1/2 and Wnt family member 3A pathways and promotes in vitro proliferation, migration and invasion of breast cancer MDA-MB-231 cells (2018), Oncol. Lett., 16, 145-150 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.61

Organism

Organism UniProt Comment Textmining
Homo sapiens P29122
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
HuPCSK6
-
 Homo sapiens
PCSK6
-
 Homo sapiens
proprotein convertase subtilisin/kexin type 6
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function recombinant PCSK6 significantly increases the proliferation, invasion and migraxadtion abilities of breast cancer MDA-MB-231 cells. In addition, PCSK6 treatment reduces cell cycle arrest and prevents apoptosis of MDA-MB-231 cells. PCSK6 treatment also increases the expression of phosphorylated extracellular signal-regulated kinase 1/2 and Wnt family member 3A, suggesting that these pathways are activated by PCSK6. Enzyme PCSK6 may promote the proliferation of breast cancer MDA-MB-231 cells by disturbing cell cycle arrest via the mitogen-activated protein kinase pathway Homo sapiens