Application | Comment | Organism |
---|---|---|
drug development | PCSK6 may become a reasonable target for the development of drugs able to control high blood pressure by directly modulating pro-ANP cleavage | Homo sapiens |
medicine | PCSK6 may become a reasonable target for the development of drugs able to control high blood pressure by directly modulating pro-ANP cleavage and, therefore, increasing endogenous circulating alphaANP levels. Such a therapeutic approach may reveal beneficial also in the treatment of heart failure | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
corin + H2O | Homo sapiens | activating processing of corin by enzyme PCSK6 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
corin + H2O | activating processing of corin by enzyme PCSK6 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
corin activating enzyme | - |
Homo sapiens |
PCSK6 | - |
Homo sapiens |
proprotein convertase subtilisin/kexin 6 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | lack of PCSK6-dependent corin activation leads to hypertension. PCSK6-mediated processing of corin is reduced in the presence of corin variants T555I and Q568P previously associated to hypertension and to heart disease | Homo sapiens |
physiological function | the enzyme is involved in pro-atrial natriuretic peptide (pro-ANP) processing in the heart, key functions of PCSK6 are in the cardiovascular system to control blood pressure homeostasis | Homo sapiens |