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Literature summary for 3.4.21.61 extracted from

  • Volpe, M.; Rubattu, S.
    Novel insights into the mechanisms regulating pro-atrial natriuretic peptide cleavage in the heart and blood pressure regulation proprotein convertase subtilisin/kexin 6 is the corin activating enzyme (2016), Circ. Res., 118, 196-198 .
    View publication on PubMed

Application

Application Comment Organism
drug development PCSK6 may become a reasonable target for the development of drugs able to control high blood pressure by directly modulating pro-ANP cleavage Homo sapiens
medicine PCSK6 may become a reasonable target for the development of drugs able to control high blood pressure by directly modulating pro-ANP cleavage and, therefore, increasing endogenous circulating alphaANP levels. Such a therapeutic approach may reveal beneficial also in the treatment of heart failure Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
corin + H2O Homo sapiens activating processing of corin by enzyme PCSK6 ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
corin + H2O activating processing of corin by enzyme PCSK6 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
corin activating enzyme
-
Homo sapiens
PCSK6
-
Homo sapiens
proprotein convertase subtilisin/kexin 6
-
Homo sapiens

General Information

General Information Comment Organism
malfunction lack of PCSK6-dependent corin activation leads to hypertension. PCSK6-mediated processing of corin is reduced in the presence of corin variants T555I and Q568P previously associated to hypertension and to heart disease Homo sapiens
physiological function the enzyme is involved in pro-atrial natriuretic peptide (pro-ANP) processing in the heart, key functions of PCSK6 are in the cardiovascular system to control blood pressure homeostasis Homo sapiens