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Literature summary for 3.4.21.61 extracted from

  • Canuel, M.; Sun, X.; Asselin, M.C.; Paramithiotis, E.; Prat, A.; Seidah, N.G.
    Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1) (2013), PLoS ONE, 8, e64145.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.61

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
low density lipoprotein receptor-related protein 1 + H2O Cricetulus griseus degradation ?
-
 ?
low density lipoprotein receptor-related protein 1 + H2O Homo sapiens degradation ?
-
 ?
low density lipoprotein receptor-related protein 1 + H2O Mus musculus degradation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Homo sapiens
-
-
-
Mus musculus Q80W65
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B16-F1 cell
-
 Mus musculus
-
B16-F10 cell
-
 Mus musculus
-
CHO-13-5-1 cell
-
 Cricetulus griseus
-
CHO-A7 cell
-
 Cricetulus griseus
-
CHO-K1 cell
-
 Cricetulus griseus
-
HEK-293 cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Mus musculus
-
melanoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
low density lipoprotein receptor-related protein 1 + H2O degradation Cricetulus griseus ?
-
 ?
low density lipoprotein receptor-related protein 1 + H2O degradation Homo sapiens ?
-
 ?
low density lipoprotein receptor-related protein 1 + H2O degradation Mus musculus ?
-
 ?
low density lipoprotein receptor-related protein 1 + H2O the enzyme acts on the extracellular domain of the receptor molecule Cricetulus griseus ?
-
 ?
low density lipoprotein receptor-related protein 1 + H2O the enzyme acts on the extracellular domain of the receptor molecule Homo sapiens ?
-
 ?
low density lipoprotein receptor-related protein 1 + H2O the enzyme acts on the extracellular domain of the receptor molecule Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
PCSK9
-
 Cricetulus griseus
PCSK9
-
 Homo sapiens
PCSK9
-
 Mus musculus
proprotein convertase subtilisin/kexin type 9 (PCSK9)Proprotein convertase subtilisin/kexin type 9
-
 Cricetulus griseus
proprotein convertase subtilisin/kexin type 9 (PCSK9)Proprotein convertase subtilisin/kexin type 9
-
 Homo sapiens
proprotein convertase subtilisin/kexin type 9 (PCSK9)Proprotein convertase subtilisin/kexin type 9
-
 Mus musculus

General Information

General Information Comment Organism
physiological function proprotein convertase subtilisin/kexin 9 enhances the degradation of the LDL receptor in endosomes/lysosomes, resulting in increased circulating LDLc. The enzyme can also mediate the degradation of LDL receptor lacking its cytosolic tail, the transmembrane-domain of the receptor is not involved, but a lysosomal-targeting factor, overview. Role for the enzyme in enhancing tumor metastasis, consequences of enzyme inhibition for lowering LDLc and tumor metastasis Homo sapiens
physiological function proprotein convertase subtilisin/kexin 9 enhances the degradation of the LDL receptor in endosomes/lysosomes, resulting in increased circulating LDLc. The enzyme can also mediate the degradation of LDL receptor lacking its cytosolic tail, the transmembrane-domain of the receptor is not involved, but a lysosomal-targeting factor.overview. The LDL receptor is insensitive to the enzyme in murine B16F1 melanoma cells, but the enzyme is able to induce degradation of the low density lipoprotein receptor-related protein 1, suggesting distinct targeting mechanisms for these receptors. Role for the enzyme in enhancing tumor metastasis Mus musculus
physiological function proprotein convertase subtilisin/kexin 9 enhances the degradation of the LDL receptor in endosomes/lysosomes, resulting in increased circulating LDLc. The enzyme is capable of acting upon the LDL receptor in CHO 13-5-1 cells lacking LRP-1. It also acts on LRP-1 in the absence of the LDL receptor in CHO-A7 cells, where re-introduction of the LDL receptor leads to reduced enzyme-mediated degradation of LRP-1 Cricetulus griseus