Any feedback?
Literature summary for 3.4.21.61 extracted from
- Affinity and kinetics of proprotein convertase subtilisin/kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells (2011), FEBS J., 278, 2938-2950.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in HEK293 cell | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D374Y | naturally occurring gain-of-function mutant causes severe hypercholesterolemia | Homo sapiens |
| S127R | naturally occurring gain-of-function mutant causes severe hypercholesterolemia | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| low density lipoprotein receptor + H2O | PCSK9 binding to cell surface low density lipoprotein receptor cannot be described by a simple bimolecular reaction. Data suggest the presence of two populations of binding site | Homo sapiens | ? | - |
? |  |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
