Literature summary for 3.4.21.61 extracted from

Davignon, J.; Dubuc, G.
Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels (2009), Trans. Am. Clin. Climatol. Assoc., 120, 163-173.

Search for more literature for 3.4.21.61

Protein Variants

Protein Variants	Comment	Organism
A433T	is associated with a plasma PCSK9 concentration of 222 ng/ml	Homo sapiens
G365R	is associated with a plasma PCSK9 concentration of 205 ng/ml	Homo sapiens
Q190R	is associated with a plasma PCSK9 concentration of 55 ng/ml	Homo sapiens
R434W	is associated with a plasma PCSK9 concentration of 51 ng/ml	Homo sapiens
R46L	is associated with a plasma PCSK9 concentration of 51-59 ng/ml	Homo sapiens
R53V	is associated with a plasma PCSK9 concentration of 39 ng/ml	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8NBP7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	in healthy volunteers, there is no significant difference in plasma PCSK9 measured between men and women	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PCSK9	-	Homo sapiens
proprotein convertase subtilisin kexin-9	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	PCSK9 levels correlate with plasma cholesterol, LDL-C, triglycerides, fasting glucose, age and body mass index. In hypercholesterolemic patients, circulating PCSK9 is higher than in healthy volunteers, and increases with increasing statin dose, and further increased when ezetimibe is added. Ezetimibe treatment of Hep-G2 (hepatocytes) and Caco-2 (enterocytes) cells causes a slight increase in PCSK9 mRNA, but no significant rise in PCSK9 protein secretion, suggesting that these transformed cells are not ideal model cell lines	up

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Release 2023.1 (January 2023)