Literature summary for 3.4.21.61 extracted from

Graham, M.J.; Lemonidis, K.M.; Whipple, C.P.; Subramaniam, A.; Monia, B.P.; Crooke, S.T.; Crooke, R.M.
Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice (2007), J. Lipid Res., 48, 763-767.

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Application

Application	Comment	Organism
medicine	antisense inhibition of PCSK9 is an attractive and novel therapeutic approach for treating hypercholesterolemia	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
ISIS 394814	most potent antisense oligonucleotide. Administration to high fat-fed mice for 6 weeks reduces hepatic PCSK9 mRNA levels by 92%, total cholesterol and LDL by 53% and 38%, respectively. Inhibition of PCSK9 expression results in a 2fold increase in hepatic LDLR protein levels	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57BL/6 mice	-
Mus musculus C57BL/6	-	C57BL/6 mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
PCSK9	-	Mus musculus
proprotein convertase subtilisin/kexin type 9	-	Mus musculus

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Release 2023.1 (January 2023)