Literature summary for 3.4.21.61 extracted from

Rozan, L.; Krysan, D.J.; Rockwell, N.C.; Fuller, R.S.
Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin (2004), J. Biol. Chem., 279, 35656-35663.

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Protein Variants

Protein Variants	Comment	Organism
E255I	significantly decreased recognition of P4Arg residue in a tetrapeptide substrate	Saccharomyces cerevisiae
T252D	increased recognition of Arg in P4 position, 14fold higher kcat/KM ratio for Arg than for Ala at position P6	Saccharomyces cerevisiae
T252D/Q283E	increased recognition of Arg in P4 position, 15fold higher kcat/KM ratio for Arg than for Ala at position P6	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

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Release 2023.1 (January 2023)