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Literature summary for 3.4.21.61 extracted from

  • Steiner, D.F.; Smeekens, S.P.; Ohagi, S.; Chan, S.J.
    The new enzymology of precursor processing endoproteases (1992), J. Biol. Chem., 267, 23435-23438.
    View publication on PubMed
Search for more literature for 3.4.21.61

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Saccharomyces cerevisiae
Ca2+ 1 mM Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-mating factor + H2O Saccharomyces cerevisiae cleavage of dibasic sites ?
-
 ?
Killer toxin precursors + H2O Saccharomyces cerevisiae cleavage of dibasic sites ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-mating factor + H2O cleavage of dibasic sites Saccharomyces cerevisiae ?
-
 ?
Killer toxin precursors + H2O cleavage of dibasic sites Saccharomyces cerevisiae ?
-
 ?
Protein + H2O specificity: preference for Lys-Arg, while Arg-Arg, Pro-Arg, Ala-Arg, and Thr-Arg are equally rapidly cleaved but with higher Km Saccharomyces cerevisiae ?
-
 ?
Protein + H2O autocatalytic activation at an internal Lys108-Arg109 Saccharomyces cerevisiae ?
-
 ?
Protein + H2O cleaves a wide variety of precursors from higher eukaryotes including prohormones, such as proinsulin and proopiomelanocortin, as well as precursors of constitutively secreteted proteins, such as proalbumin Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
More similar enzymes occurs in mammals Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 9.5
-
 Saccharomyces cerevisiae