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Literature summary for 3.4.21.60 extracted from

  • Chen, L.; Rezaie, A.R.
    Proexosite-1-dependent recognition and activation of prothrombin by taipan venom (2004), J. Biol. Chem., 279, 17869-17874.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
hirudin54-65(SO-3)-
-
Oxyuranus scutellatus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0022
-
prethrombin-1 pH 7.5 Oxyuranus scutellatus
0.5
-
prothrombin pH 7.5 Oxyuranus scutellatus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
1 * 50000 + x * ?, catalytically active subunit, SDS-PAGE Oxyuranus scutellatus
220000
-
gel filtration Oxyuranus scutellatus

Organism

Organism UniProt Comment Textmining
Oxyuranus scutellatus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially Oxyuranus scutellatus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prethrombin-1 + H2O
-
Oxyuranus scutellatus ?
-
?
prothrombin + H2O
-
Oxyuranus scutellatus thrombin + ?
-
?

Subunits

Subunits Comment Organism
oligomer 1 * 50000 + x * ?, catalytically active subunit, SDS-PAGE Oxyuranus scutellatus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1200
-
prothrombin pH 7.5 Oxyuranus scutellatus