Inhibitors | Comment | Organism | Structure |
---|---|---|---|
rivaroxaban | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | Homo sapiens | - |
trhombin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
atrial tissue | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
prothrombin + H2O | - |
Homo sapiens | trhombin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor Xa | - |
Homo sapiens |
FXa | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | activated factor Xa is an important player in the coagulation cascade responsible for thrombin generation, which is activated during atrial fibrillation. Factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue. FXa and tachyarrhythmia act synergistically to increase expression of protease-activated receptors and inflammatory mediators | Homo sapiens |