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Literature summary for 3.4.21.6 extracted from

  • Bukowska, A.; Zacharias, I.; Weinert, S.; Skopp, K.; Hartmann, C.; Huth, C.; Goette, A.
    Coagulation factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue (2013), Eur. J. Pharmacol., 718, 114-123.
    View publication on PubMed
Search for more literature for 3.4.21.6

Inhibitors

Inhibitors Comment Organism Structure
rivaroxaban
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prothrombin + H2O Homo sapiens
-
 trhombin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
atrial tissue
-
 Homo sapiens
-
heart
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothrombin + H2O
-
 Homo sapiens trhombin + ?
-
 ?

Synonyms

Synonyms Comment Organism
factor Xa
-
 Homo sapiens
FXa
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function activated factor Xa is an important player in the coagulation cascade responsible for thrombin generation, which is activated during atrial fibrillation. Factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue. FXa and tachyarrhythmia act synergistically to increase expression of protease-activated receptors and inflammatory mediators Homo sapiens