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Literature summary for 3.4.21.6 extracted from

  • Boehm, A.; Floesser, A.; Ermler, S.; Fender, A.C.; Lueth, A.; Kleuser, B.; Schroer, K.; Rauch, B.H.
    Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells (2013), Cardiovasc. Res., 99, 505-513.
    View publication on PubMed
Search for more literature for 3.4.21.6

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prothrombin + H2O Homo sapiens
-
 trhombin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothrombin + H2O
-
 Homo sapiens trhombin + ?
-
 ?

Synonyms

Synonyms Comment Organism
factor Xa
-
 Homo sapiens
FXa
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and sphingosine-1-phosphate formation in human vascular smooth muscle cells. Factor Xa induces sphingosine kinase-1 expression and increases sphingosine-1-phosphate formation independent of thrombin, involving the activation of Rho A and protein kinase C signalling Homo sapiens